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NCIT_C1381 IAO_0000115 "The hydrochloride salt of a semisynthetic derivative of camptothecin, a cytotoxic, quinoline-based alkaloid extracted from the Asian tree Camptotheca acuminata. Irinotecan, a prodrug, is converted to a biologically active metabolite 7-ethyl-10-hydroxy-camptothecin (SN-38) by a carboxylesterase-converting enzyme. One thousand-fold more potent than its parent compound irinotecan, SN-38 inhibits topoisomerase I activity by stabilizing the cleavable complex between topoisomerase I and DNA, resulting in DNA breaks that inhibit DNA replication and trigger apoptotic cell death. Because ongoing DNA synthesis is necessary for irinotecan to exert its cytotoxic effects, it is classified as an S-phase-specific agent." @default.
NCIT_C1381 NCIT_A32 NCIT_C1909 @default.
NCIT_C1381 NCIT_A6 NCIT_C62040 @default.
NCIT_C1381 NCIT_A7 NCIT_C16516 @default.
NCIT_C1381 NCIT_NHC0 "C1381" @default.
NCIT_C1381 NCIT_P106 "Organic Chemical" @default.
NCIT_C1381 NCIT_P106 "Pharmacologic Substance" @default.
NCIT_C1381 NCIT_P107 "Irinotecan Hydrochloride" @default.
NCIT_C1381 NCIT_P108 "Irinotecan Hydrochloride" @default.
NCIT_C1381 NCIT_P207 "C0594375" @default.
NCIT_C1381 NCIT_P210 "136572-09-3" @default.
NCIT_C1381 NCIT_P302 "State IVB Cervical cancer; Colorectal cancer; Esophageal cancer; Gastric cancer; Non-small cell lung cancer; Small cell lung cancer" @default.
NCIT_C1381 NCIT_P319 "042LAQ1IIS" @default.
NCIT_C1381 NCIT_P322 "CTRP" @default.
NCIT_C1381 NCIT_P322 "FDA" @default.
NCIT_C1381 NCIT_P322 "GDC" @default.
NCIT_C1381 NCIT_P325 "A drug used alone or with other drugs to treat colon cancer or rectal cancer that has spread to other parts of the body or has come back after treatment with fluorouracil. It is also being studied in the treatment of other types of cancer. Camptosar blocks certain enzymes needed for cell division and DNA repair, and it may kill cancer cells. It is a type of topoisomerase inhibitor and a type of camptothecin analog." @default.
NCIT_C1381 NCIT_P329 "41714" @default.
NCIT_C1381 NCIT_P330 "41714" @default.
NCIT_C1381 NCIT_P350 "C33H38N4O6.HCl.3H2O" @default.
NCIT_C1381 NCIT_P366 "Irinotecan" @default.
NCIT_C1381 NCIT_P375 "Irinotecan Hydrochloride" @default.
NCIT_C1381 NCIT_P399 "41714" @default.
NCIT_C1381 NCIT_R122 NCIT_C16484 @default.
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NCIT_C1381 NCIT_R125 NCIT_C25830 @default.
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NCIT_C1381 NCIT_R146 NCIT_C16516 @default.
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NCIT_C1381 NCIT_R146 NCIT_C20027 @default.
NCIT_C1381 NCIT_R146 NCIT_C20646 @default.
NCIT_C1381 NCIT_R146 NCIT_C26548 @default.
NCIT_C1381 normalizedInformationContent "69.660526824782636" @default.
NCIT_C1381 referenceCount "98" @default.
NCIT_C1381 hasExactSynonym "CPT 11" @default.
NCIT_C1381 hasExactSynonym "CPT-11" @default.
NCIT_C1381 hasExactSynonym "Campto" @default.
NCIT_C1381 hasExactSynonym "Camptosar" @default.
NCIT_C1381 hasExactSynonym "Camptothecin 11" @default.
NCIT_C1381 hasExactSynonym "Camptothecin-11" @default.
NCIT_C1381 hasExactSynonym "IRINOTECAN HYDROCHLORIDE" @default.
NCIT_C1381 hasExactSynonym "Irinomedac" @default.
NCIT_C1381 hasExactSynonym "Irinotecan Hydrochloride Trihydrate" @default.
NCIT_C1381 hasExactSynonym "Irinotecan Hydrochloride" @default.
NCIT_C1381 hasExactSynonym "Irinotecan Monohydrochloride Trihydrate" @default.
NCIT_C1381 hasExactSynonym "U-101440E" @default.
NCIT_C1381 hasExactSynonym "irinotecan hydrochloride" @default.
NCIT_C1381 inSubset NCIT_C116977 @default.
NCIT_C1381 inSubset NCIT_C116978 @default.
NCIT_C1381 inSubset NCIT_C128784 @default.
NCIT_C1381 inSubset NCIT_C157711 @default.
NCIT_C1381 inSubset NCIT_C157712 @default.
NCIT_C1381 inSubset NCIT_C176424 @default.
NCIT_C1381 inSubset NCIT_C177537 @default.
NCIT_C1381 inSubset NCIT_C63923 @default.
NCIT_C1381 type Class @default.
NCIT_C1381 isDefinedBy ncit.owl @default.
NCIT_C1381 label "Irinotecan Hydrochloride" @default.
NCIT_C1381 subClassOf B011f2bb6988045e8750c0be3b8817841 @default.
NCIT_C1381 subClassOf B0dc42aeb60b132c715b057c739865e16 @default.
NCIT_C1381 subClassOf B1914cedb05cf3e13465a0528faf1ca4c @default.
NCIT_C1381 subClassOf B3fdc682c124810bf3ab188c4d067393e @default.
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NCIT_C1381 subClassOf B631e13427c33fb8be9a96322fdc29981 @default.
NCIT_C1381 subClassOf B6e2bd72644181a03576a46f6d3cad361 @default.
NCIT_C1381 subClassOf B71ea16df291dd5dbeca1294f42011629 @default.