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- NCIT_C138165 IAO_0000115 "An orally bioavailable inhibitor of cyclin-dependent kinase (CDK) types 4 (CDK4) and 6 (CDK6), with potential antineoplastic activity. Upon administration, lerociclib selectively inhibits CDK4 and CDK6, which inhibits the phosphorylation of retinoblastoma protein (Rb) early in the G1 phase, prevents CDK-mediated G1-S phase transition and leads to cell cycle arrest. This suppresses DNA replication and decreases tumor cell proliferation. CDK4 and 6 are serine/threonine kinases that are upregulated in many tumor cell types and play a key role in the regulation of both cell cycle progression from the G1-phase into the S-phase and tumor cell proliferation." @default.
- NCIT_C138165 NCIT_A32 NCIT_C1909 @default.
- NCIT_C138165 NCIT_A7 NCIT_C17680 @default.
- NCIT_C138165 NCIT_A7 NCIT_C97386 @default.
- NCIT_C138165 NCIT_NHC0 "C138165" @default.
- NCIT_C138165 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C138165 NCIT_P107 "Lerociclib" @default.
- NCIT_C138165 NCIT_P108 "Lerociclib" @default.
- NCIT_C138165 NCIT_P208 "CL525730" @default.
- NCIT_C138165 NCIT_P210 "1628256-23-4" @default.
- NCIT_C138165 NCIT_P319 "WBH8AY6ENB" @default.
- NCIT_C138165 NCIT_P322 "CTRP" @default.
- NCIT_C138165 NCIT_P322 "FDA" @default.
- NCIT_C138165 NCIT_P322 "GDC" @default.
- NCIT_C138165 NCIT_P329 "790539" @default.
- NCIT_C138165 NCIT_P330 "790539" @default.
- NCIT_C138165 NCIT_P375 "CDK4/6 Inhibitor G1T38" @default.
- NCIT_C138165 NCIT_P375 "Lerociclib" @default.
- NCIT_C138165 NCIT_P399 "790539" @default.
- NCIT_C138165 normalizedInformationContent "100" @default.
- NCIT_C138165 referenceCount "1" @default.
- NCIT_C138165 hasExactSynonym "7',8'-Dihydro-2'-((5-(4-(1-methylethyl)-1-piperazinyl)-2-pyridinyl)amino)spiro(cyclohexane-1,9'(6'H)-pyrazino(1',2':1,5)pyrrolo(2,3-d)pyrimidin)-6'-one" @default.
- NCIT_C138165 hasExactSynonym "CDK4/6 Inhibitor G1T38" @default.
- NCIT_C138165 hasExactSynonym "G1T38 Free Base" @default.
- NCIT_C138165 hasExactSynonym "G1T38" @default.
- NCIT_C138165 hasExactSynonym "GB 491" @default.
- NCIT_C138165 hasExactSynonym "GB-491" @default.
- NCIT_C138165 hasExactSynonym "GB491" @default.
- NCIT_C138165 hasExactSynonym "LEROCICLIB" @default.
- NCIT_C138165 hasExactSynonym "Lerociclib" @default.
- NCIT_C138165 inSubset NCIT_C116977 @default.
- NCIT_C138165 inSubset NCIT_C116978 @default.
- NCIT_C138165 inSubset NCIT_C128784 @default.
- NCIT_C138165 inSubset NCIT_C157711 @default.
- NCIT_C138165 inSubset NCIT_C157712 @default.
- NCIT_C138165 inSubset NCIT_C176424 @default.
- NCIT_C138165 inSubset NCIT_C177537 @default.
- NCIT_C138165 inSubset NCIT_C63923 @default.
- NCIT_C138165 type Class @default.
- NCIT_C138165 isDefinedBy ncit.owl @default.
- NCIT_C138165 label "Lerociclib" @default.
- NCIT_C138165 subClassOf NCIT_C129824 @default.
- NCIT_C138165 subClassOf NCIT_C129825 @default.
- NCIT_C138165 subClassOf NCIT_C138165 @default.
- NCIT_C138165 subClassOf NCIT_C1404 @default.
- NCIT_C138165 subClassOf NCIT_C163758 @default.
- NCIT_C138165 subClassOf NCIT_C1908 @default.
- NCIT_C138165 subClassOf NCIT_C1909 @default.
- NCIT_C138165 subClassOf NCIT_C192741 @default.
- NCIT_C138165 subClassOf NCIT_C192742 @default.
- NCIT_C138165 subClassOf NCIT_C2185 @default.
- NCIT_C138165 subClassOf NCIT_C2189 @default.
- NCIT_C138165 subClassOf NCIT_C274 @default.
- NCIT_C138165 subClassOf NCIT_C471 @default.
- NCIT_C138165 subClassOf NCIT_C61074 @default.