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- NCIT_C1382 IAO_0000115 "An indolocarbazole-based alkaloid and staurosporine analog isolated from Nocardiopsis and Actinomadura species, with kinase inhibiting activity. K252a inhibits a wide variety of enzymes, including, but not limited to, protein kinase A (PKA), C (PKC) and G (PKG), calcium (Ca2+)/calmodulin-dependent kinase type II (CaMKII), phosphorylase kinase (PhK), tropomyosin receptor kinase (Trk; neurotrophic tyrosine receptor kinase; NTRK), myosin light-chain kinase (MLCK; MYLK), mixed-lineage protein kinase 3 (MLK3), receptor-type tyrosine-protein kinase FLT3 (CD135; fms-like tyrosine kinase 3; fetal liver kinase-2; FLK2) and actin-regulating kinase PRK1 (PAK1). Inhibition of these kinases prevents the activation of signaling pathways in which these kinases play a key role." @default.
- NCIT_C1382 NCIT_NHC0 "C1382" @default.
- NCIT_C1382 NCIT_P106 "Organic Chemical" @default.
- NCIT_C1382 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C1382 NCIT_P108 "K 252a" @default.
- NCIT_C1382 NCIT_P207 "C0124355" @default.
- NCIT_C1382 NCIT_P210 "99533-80-9" @default.
- NCIT_C1382 NCIT_P319 "IV7H45AM5B" @default.
- NCIT_C1382 NCIT_P322 "FDA" @default.
- NCIT_C1382 NCIT_P350 "C27H21N3O5" @default.
- NCIT_C1382 NCIT_P366 "K_252a" @default.
- NCIT_C1382 normalizedInformationContent "100" @default.
- NCIT_C1382 referenceCount "1" @default.
- NCIT_C1382 hasExactSynonym "9,1-Epoxy-1H-diindolo(1,2,3-fg:3',2',1'-kl)pyrrolo(3,4-i)(1,6)benzodiazocine-10-carboxylic acid, 2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-, methyl ester, (9-alpha,10-beta,12-alpha)-" @default.
- NCIT_C1382 hasExactSynonym "Antibiotic K 252A" @default.
- NCIT_C1382 hasExactSynonym "Antibiotic SF 2370" @default.
- NCIT_C1382 hasExactSynonym "K 252a" @default.
- NCIT_C1382 hasExactSynonym "K-252a" @default.
- NCIT_C1382 hasExactSynonym "K252A" @default.
- NCIT_C1382 hasExactSynonym "Protein Kinase Inhibitor K252a" @default.
- NCIT_C1382 hasExactSynonym "SF 2370" @default.
- NCIT_C1382 inSubset NCIT_C63923 @default.
- NCIT_C1382 type Class @default.
- NCIT_C1382 isDefinedBy ncit.owl @default.
- NCIT_C1382 label "K 252a" @default.
- NCIT_C1382 subClassOf NCIT_C1382 @default.
- NCIT_C1382 subClassOf NCIT_C1404 @default.
- NCIT_C1382 subClassOf NCIT_C1908 @default.
- NCIT_C1382 subClassOf NCIT_C1909 @default.
- NCIT_C1382 subClassOf NCIT_C471 @default.