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- NCIT_C1383 IAO_0000115 "A synthetic liposomal formulation of bis-neodecanoate diaminocyclohexane platinum (NDDP), a third-generation platinum complex analogue of cisplatin, with potential antineoplastic activity. After displacement of the 2 long-chain aliphatic leaving groups (neodecanoic acid), platinum diaminocyclohexane (DACH) complexes become highly reactive and alkylate macromolecules, forming both inter- and intra-stranded DNA cross-linkings and inhibiting DNA synthesis, which results in tumor cell cytotoxicity. Because DNA mismatch-repair (MMR) complexes do not recognize DACH-platinum adducts, DNA repair mechanisms are inhibited, overcoming limitations observed with other platinum-based agents. In addition, the liposomal encapsulation improves the bioavailability of NDDP and reduces its toxicity profile." @default.
- NCIT_C1383 NCIT_A32 NCIT_C1909 @default.
- NCIT_C1383 NCIT_A7 NCIT_C449 @default.
- NCIT_C1383 NCIT_NHC0 "C1383" @default.
- NCIT_C1383 NCIT_P106 "Organic Chemical" @default.
- NCIT_C1383 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C1383 NCIT_P108 "Liposomal NDDP" @default.
- NCIT_C1383 NCIT_P207 "C0125061" @default.
- NCIT_C1383 NCIT_P210 "114488-24-3" @default.
- NCIT_C1383 NCIT_P319 "J7M4Z2D183" @default.
- NCIT_C1383 NCIT_P322 "FDA" @default.
- NCIT_C1383 NCIT_P322 "GDC" @default.
- NCIT_C1383 NCIT_P329 "43010" @default.
- NCIT_C1383 NCIT_P330 "43010" @default.
- NCIT_C1383 NCIT_P366 "Liposomal-Cisplatin_Analogue" @default.
- NCIT_C1383 NCIT_P375 "Liposomal NDDP" @default.
- NCIT_C1383 NCIT_P399 "43010" @default.
- NCIT_C1383 NCIT_R124 NCIT_C16507 @default.
- NCIT_C1383 NCIT_R124 NCIT_C16956 @default.
- NCIT_C1383 NCIT_R124 NCIT_C17828 @default.
- NCIT_C1383 NCIT_R124 NCIT_C18264 @default.
- NCIT_C1383 NCIT_R124 NCIT_C19154 @default.
- NCIT_C1383 NCIT_R124 NCIT_C25827 @default.
- NCIT_C1383 NCIT_R125 NCIT_C17710 @default.
- NCIT_C1383 NCIT_R125 NCIT_C17828 @default.
- NCIT_C1383 NCIT_R125 NCIT_C18125 @default.
- NCIT_C1383 NCIT_R125 NCIT_C19077 @default.
- NCIT_C1383 NCIT_R125 NCIT_C21049 @default.
- NCIT_C1383 NCIT_R125 NCIT_C21050 @default.
- NCIT_C1383 NCIT_R125 NCIT_C21080 @default.
- NCIT_C1383 NCIT_R125 NCIT_C28498 @default.
- NCIT_C1383 NCIT_R125 NCIT_C40664 @default.
- NCIT_C1383 NCIT_R125 NCIT_C40692 @default.
- NCIT_C1383 NCIT_R125 NCIT_C41543 @default.
- NCIT_C1383 normalizedInformationContent "100" @default.
- NCIT_C1383 referenceCount "1" @default.
- NCIT_C1383 hasExactSynonym "AROPLATIN" @default.
- NCIT_C1383 hasExactSynonym "Aroplatin" @default.
- NCIT_C1383 hasExactSynonym "L-NDDP" @default.
- NCIT_C1383 hasExactSynonym "Liposomal NDDP" @default.
- NCIT_C1383 hasExactSynonym "Liposomal Neodecanoic Acid Platinum Complex" @default.
- NCIT_C1383 hasExactSynonym "Liposomal-Cisplatin Analogue" @default.
- NCIT_C1383 hasExactSynonym "Liposomal-Entrapped Cis-Bis-Neodecanoate-trans-R,R-1,2-Diaminocyclohexane Platinum (II)" @default.
- NCIT_C1383 inSubset NCIT_C128784 @default.
- NCIT_C1383 inSubset NCIT_C157711 @default.
- NCIT_C1383 inSubset NCIT_C157712 @default.
- NCIT_C1383 inSubset NCIT_C176424 @default.
- NCIT_C1383 inSubset NCIT_C177537 @default.
- NCIT_C1383 inSubset NCIT_C63923 @default.
- NCIT_C1383 type Class @default.
- NCIT_C1383 isDefinedBy ncit.owl @default.
- NCIT_C1383 label "Liposomal NDDP" @default.
- NCIT_C1383 subClassOf B1cb8be2bdcf0aff46252e6e5a9e3c2b6 @default.
- NCIT_C1383 subClassOf B3fc93912a8be974d37d8e9628726a8b9 @default.
- NCIT_C1383 subClassOf B577956dafce39ffe73cfb6343edd1f6b @default.
- NCIT_C1383 subClassOf B67dc2b466c2da967c210c8b3cae69060 @default.
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- NCIT_C1383 subClassOf NCIT_C1383 @default.
- NCIT_C1383 subClassOf NCIT_C1450 @default.
- NCIT_C1383 subClassOf NCIT_C1590 @default.
- NCIT_C1383 subClassOf NCIT_C186664 @default.
- NCIT_C1383 subClassOf NCIT_C1908 @default.
- NCIT_C1383 subClassOf NCIT_C1909 @default.
- NCIT_C1383 subClassOf NCIT_C2163 @default.
- NCIT_C1383 subClassOf NCIT_C274 @default.
- NCIT_C1383 subClassOf NCIT_C2842 @default.
- NCIT_C1383 subClassOf NCIT_C798 @default.