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- NCIT_C138995 IAO_0000115 "The hydrochloride salt form of capmatinib, an orally bioavailable inhibitor of the proto-oncogene c-Met (also known as hepatocyte growth factor receptor (HGFR)) with potential antineoplastic activity. Capmatinib selectively binds to c-Met, thereby inhibiting c-Met phosphorylation and disrupting c-Met signal transduction pathways. This may induce cell death in tumor cells overexpressing c-Met protein or expressing constitutively activated c-Met protein. c-Met, a receptor tyrosine kinase overexpressed or mutated in many tumor cell types, plays key roles in tumor cell proliferation, survival, invasion, metastasis, and tumor angiogenesis." @default.
- NCIT_C138995 NCIT_A6 NCIT_C90564 @default.
- NCIT_C138995 NCIT_A7 NCIT_C18186 @default.
- NCIT_C138995 NCIT_NHC0 "C138995" @default.
- NCIT_C138995 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C138995 NCIT_P107 "Capmatinib Hydrochloride" @default.
- NCIT_C138995 NCIT_P108 "Capmatinib Hydrochloride" @default.
- NCIT_C138995 NCIT_P208 "CL526448" @default.
- NCIT_C138995 NCIT_P210 "1865733-40-9" @default.
- NCIT_C138995 NCIT_P302 "treatment of adult patients with metastatic non-small cell lung cancer (NSCLC) whose tumors have a mutation that leads to mesenchymal-epithelial transition (MET) exon 14 skipping as detected by an FDA-approved test." @default.
- NCIT_C138995 NCIT_P319 "C2A374O70X" @default.
- NCIT_C138995 NCIT_P322 "CTRP" @default.
- NCIT_C138995 NCIT_P322 "FDA" @default.
- NCIT_C138995 NCIT_P329 "666907" @default.
- NCIT_C138995 NCIT_P330 "666907" @default.
- NCIT_C138995 NCIT_P399 "666907" @default.
- NCIT_C138995 normalizedInformationContent "95.413332725061409" @default.
- NCIT_C138995 referenceCount "2" @default.
- NCIT_C138995 hasExactSynonym "CAPMATINIB HYDROCHLORIDE" @default.
- NCIT_C138995 hasExactSynonym "Capmatinib Hydrochloride" @default.
- NCIT_C138995 hasExactSynonym "NVP-INC280-AAA" @default.
- NCIT_C138995 hasExactSynonym "Tabrecta" @default.
- NCIT_C138995 inSubset NCIT_C116977 @default.
- NCIT_C138995 inSubset NCIT_C116978 @default.
- NCIT_C138995 inSubset NCIT_C176424 @default.
- NCIT_C138995 inSubset NCIT_C63923 @default.
- NCIT_C138995 type Class @default.
- NCIT_C138995 isDefinedBy ncit.owl @default.
- NCIT_C138995 label "Capmatinib Hydrochloride" @default.
- NCIT_C138995 subClassOf NCIT_C129824 @default.
- NCIT_C138995 subClassOf NCIT_C129825 @default.
- NCIT_C138995 subClassOf NCIT_C138995 @default.
- NCIT_C138995 subClassOf NCIT_C1404 @default.
- NCIT_C138995 subClassOf NCIT_C143099 @default.
- NCIT_C138995 subClassOf NCIT_C163758 @default.
- NCIT_C138995 subClassOf NCIT_C164000 @default.
- NCIT_C138995 subClassOf NCIT_C1908 @default.
- NCIT_C138995 subClassOf NCIT_C1909 @default.
- NCIT_C138995 subClassOf NCIT_C1967 @default.
- NCIT_C138995 subClassOf NCIT_C2189 @default.
- NCIT_C138995 subClassOf NCIT_C274 @default.
- NCIT_C138995 subClassOf NCIT_C471 @default.