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- NCIT_C1390 IAO_0000115 "A nonsedating derivative of thiobarbituric acid and a novel catalytic topoisomerase II inhibitor with antineoplastic activity. Merbarone interferes with DNA replication via binding directly to topoisomerase II at a domain that maybe shared by other topoisomerase II cleavage-enhancing agents, ex., etoposide. Its mechanism of action appears to be a novel one, since merbarone does not intercalate DNA nor stabilize DNA-topoisomerase II cleavable complexes." @default.
- NCIT_C1390 NCIT_A32 NCIT_C1909 @default.
- NCIT_C1390 NCIT_NHC0 "C1390" @default.
- NCIT_C1390 NCIT_P106 "Organic Chemical" @default.
- NCIT_C1390 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C1390 NCIT_P108 "Merbarone" @default.
- NCIT_C1390 NCIT_P175 "336628" @default.
- NCIT_C1390 NCIT_P207 "C0127565" @default.
- NCIT_C1390 NCIT_P210 "97534-21-9" @default.
- NCIT_C1390 NCIT_P319 "YWB9IF596V" @default.
- NCIT_C1390 NCIT_P322 "FDA" @default.
- NCIT_C1390 NCIT_P322 "GDC" @default.
- NCIT_C1390 NCIT_P329 "40220" @default.
- NCIT_C1390 NCIT_P330 "40220" @default.
- NCIT_C1390 NCIT_P366 "Merbarone" @default.
- NCIT_C1390 NCIT_P375 "Merbarone" @default.
- NCIT_C1390 NCIT_P399 "40220" @default.
- NCIT_C1390 normalizedInformationContent "95.413332725061409" @default.
- NCIT_C1390 referenceCount "2" @default.
- NCIT_C1390 hasExactSynonym "MERBARONE" @default.
- NCIT_C1390 hasExactSynonym "Merbarone" @default.
- NCIT_C1390 inSubset NCIT_C128784 @default.
- NCIT_C1390 inSubset NCIT_C157711 @default.
- NCIT_C1390 inSubset NCIT_C157712 @default.
- NCIT_C1390 inSubset NCIT_C176424 @default.
- NCIT_C1390 inSubset NCIT_C177537 @default.
- NCIT_C1390 inSubset NCIT_C63923 @default.
- NCIT_C1390 type Class @default.
- NCIT_C1390 isDefinedBy ncit.owl @default.
- NCIT_C1390 label "Merbarone" @default.
- NCIT_C1390 subClassOf NCIT_C129824 @default.
- NCIT_C1390 subClassOf NCIT_C129825 @default.
- NCIT_C1390 subClassOf NCIT_C1390 @default.
- NCIT_C1390 subClassOf NCIT_C1748 @default.
- NCIT_C1390 subClassOf NCIT_C1908 @default.
- NCIT_C1390 subClassOf NCIT_C1909 @default.
- NCIT_C1390 subClassOf NCIT_C1968 @default.
- NCIT_C1390 subClassOf NCIT_C2189 @default.
- NCIT_C1390 subClassOf NCIT_C274 @default.
- NCIT_C1390 subClassOf NCIT_C471 @default.