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- NCIT_C139003 IAO_0000115 "A nanoparticle-based prodrug formulation consisting of polymeric micelles encapsulating the anthracycline epirubicin, with potential antineoplastic activity. Epirubicin is covalently bound to polyethylene glycol (PEG) polyaspartate block copolymers through an acid-labile hydrazone bond and, upon suspension in an aqueous solution, a micellar structure with an outer hydrophilic PEG shell surrounding the hydrophobic epirubicin is formed. Upon administration of the micellar nanoparticle-encapsulated epirubicin, the nanoparticles are stable in the bloodstream and specifically accumulate in the tumor tissue. Due to the acidic conditions in the tumor and the pH-responsive nature of the micelles, epirubicin is released in the tumor milieu; it then intercalates into DNA and inhibits topoisomerase II, which inhibits DNA replication and interferes with synthesis of both RNA and protein. Compared to the administration of epirubicin alone, this formulation increases the water-solubility of epirubicin and increases its therapeutic effect while decreasing its cardiotoxicity." @default.
- NCIT_C139003 NCIT_A32 NCIT_C1909 @default.
- NCIT_C139003 NCIT_A7 NCIT_C18434 @default.
- NCIT_C139003 NCIT_NHC0 "C139003" @default.
- NCIT_C139003 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C139003 NCIT_P107 "Micellar Nanoparticle-encapsulated Epirubicin" @default.
- NCIT_C139003 NCIT_P108 "Micellar Nanoparticle-encapsulated Epirubicin" @default.
- NCIT_C139003 NCIT_P207 "C2974723" @default.
- NCIT_C139003 NCIT_P319 "RQU6X0IM9R" @default.
- NCIT_C139003 NCIT_P322 "CTRP" @default.
- NCIT_C139003 NCIT_P322 "FDA" @default.
- NCIT_C139003 NCIT_P322 "GDC" @default.
- NCIT_C139003 NCIT_P329 "790960" @default.
- NCIT_C139003 NCIT_P330 "790960" @default.
- NCIT_C139003 NCIT_P375 "Micellar Nanoparticle-encapsulated Epirubicin" @default.
- NCIT_C139003 NCIT_P399 "790960" @default.
- NCIT_C139003 normalizedInformationContent "100" @default.
- NCIT_C139003 referenceCount "1" @default.
- NCIT_C139003 hasExactSynonym "Epirubicin-incorporating Micelle" @default.
- NCIT_C139003 hasExactSynonym "K-912" @default.
- NCIT_C139003 hasExactSynonym "Micellar Nanoparticle-encapsulated Epirubicin" @default.
- NCIT_C139003 hasExactSynonym "NC-6300" @default.
- NCIT_C139003 hasExactSynonym "Nanoparticle Epirubicin" @default.
- NCIT_C139003 inSubset NCIT_C116977 @default.
- NCIT_C139003 inSubset NCIT_C116978 @default.
- NCIT_C139003 inSubset NCIT_C128784 @default.
- NCIT_C139003 inSubset NCIT_C157711 @default.
- NCIT_C139003 inSubset NCIT_C157712 @default.
- NCIT_C139003 inSubset NCIT_C176424 @default.
- NCIT_C139003 inSubset NCIT_C177537 @default.
- NCIT_C139003 inSubset NCIT_C63923 @default.
- NCIT_C139003 type Class @default.
- NCIT_C139003 isDefinedBy ncit.owl @default.
- NCIT_C139003 label "Micellar Nanoparticle-encapsulated Epirubicin" @default.
- NCIT_C139003 subClassOf NCIT_C129824 @default.
- NCIT_C139003 subClassOf NCIT_C129825 @default.
- NCIT_C139003 subClassOf NCIT_C139003 @default.
- NCIT_C139003 subClassOf NCIT_C1594 @default.
- NCIT_C139003 subClassOf NCIT_C1748 @default.
- NCIT_C139003 subClassOf NCIT_C186664 @default.
- NCIT_C139003 subClassOf NCIT_C1908 @default.
- NCIT_C139003 subClassOf NCIT_C1909 @default.
- NCIT_C139003 subClassOf NCIT_C1968 @default.
- NCIT_C139003 subClassOf NCIT_C2115 @default.
- NCIT_C139003 subClassOf NCIT_C2161 @default.
- NCIT_C139003 subClassOf NCIT_C2189 @default.
- NCIT_C139003 subClassOf NCIT_C259 @default.
- NCIT_C139003 subClassOf NCIT_C274 @default.
- NCIT_C139003 subClassOf NCIT_C2842 @default.
- NCIT_C139003 subClassOf NCIT_C471 @default.