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- NCIT_C13912 IAO_0000115 "Found in proteins that regulate apoptosis, conserved a-helix BCL-2 Homology (BH1-4) Domains are critical to protein apoptotic function and the protein ability to interact/dimerize with other family members or regulatory proteins. BH1 contains predominantly hydrophobic residues. BCL-2 family proteins dimerize among pro- and anti-apoptotic class family members. BCL-2 homodimerization appears to involve head-to-tail interaction of N-terminal BH4 resides with more distal BH1, BH2, and BH3 regions. BCL-2/BAX heterodimerization appears to involve tail-to-tail interaction of the BCL-2 BH1, BH2, and BH3 regions and the BAX BH3 domain region. BCL-2 may suppress cell death partly by binding to BAX via the BH3 domain preventing BAX homodimer formation. (NCI)" @default.
- NCIT_C13912 NCIT_NHC0 "C13912" @default.
- NCIT_C13912 NCIT_P106 "Amino Acid Sequence" @default.
- NCIT_C13912 NCIT_P108 "BH1 Domain" @default.
- NCIT_C13912 NCIT_P207 "C1511010" @default.
- NCIT_C13912 NCIT_P366 "BH1_Domain" @default.
- NCIT_C13912 normalizedInformationContent "87.123597049860606" @default.
- NCIT_C13912 referenceCount "7" @default.
- NCIT_C13912 hasExactSynonym "BCL-2 Homology 1 Domain" @default.
- NCIT_C13912 hasExactSynonym "BH1 Domain" @default.
- NCIT_C13912 type Class @default.
- NCIT_C13912 isDefinedBy ncit.owl @default.
- NCIT_C13912 label "BH1 Domain" @default.
- NCIT_C13912 subClassOf NCIT_C12219 @default.
- NCIT_C13912 subClassOf NCIT_C13303 @default.
- NCIT_C13912 subClassOf NCIT_C13379 @default.
- NCIT_C13912 subClassOf NCIT_C13426 @default.
- NCIT_C13912 subClassOf NCIT_C13671 @default.
- NCIT_C13912 subClassOf NCIT_C13911 @default.
- NCIT_C13912 subClassOf NCIT_C13912 @default.
- NCIT_C13912 subClassOf NCIT_C14134 @default.
- NCIT_C13912 subClassOf NCIT_C21599 @default.