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- NCIT_C1395 IAO_0000115 "The ditartrate salt of a semisynthetic vinca alkaloid derived from the leaves of the periwinkle plant (Vinca rosea) with antineoplastic properties. Vinorelbine binds to tubulin, thereby inhibiting tubulin polymerization into microtubules and spindle formation and resulting in apoptosis of susceptible cancer cells. Inhibition of mitotic microtubules correlates with antitumor activity, whereas inhibition of axonal microtubules seems to correlate with vinorelbine's neurotoxicity. Compared to related vinca alkaloids, vinorelbine is more selective against mitotic than axonal microtubules in vitro, which may account for its decreased neurotoxicity. This agent is also a radiation-sensitizing agent. (NCI04)" @default.
- NCIT_C1395 NCIT_A32 NCIT_C1909 @default.
- NCIT_C1395 NCIT_A6 NCIT_C1275 @default.
- NCIT_C1395 NCIT_A7 NCIT_C129655 @default.
- NCIT_C1395 NCIT_NHC0 "C1395" @default.
- NCIT_C1395 NCIT_P106 "Organic Chemical" @default.
- NCIT_C1395 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C1395 NCIT_P107 "Vinorelbine Tartrate" @default.
- NCIT_C1395 NCIT_P108 "Vinorelbine Tartrate" @default.
- NCIT_C1395 NCIT_P175 "608210" @default.
- NCIT_C1395 NCIT_P207 "C0377401" @default.
- NCIT_C1395 NCIT_P210 "125317-39-7" @default.
- NCIT_C1395 NCIT_P302 "Non-small cell lung cancer; metastatic breast cancer; uterine and cervical cancer; desmoid tumors; advanced Kaposi's sarcoma" @default.
- NCIT_C1395 NCIT_P319 "253GQW851Q" @default.
- NCIT_C1395 NCIT_P322 "CTRP" @default.
- NCIT_C1395 NCIT_P322 "FDA" @default.
- NCIT_C1395 NCIT_P322 "GDC" @default.
- NCIT_C1395 NCIT_P325 "A drug used to treat advanced non-small cell lung cancer. It blocks cell growth by stopping cell division and may cause cancer cells to die. It is a type of vinca alkaloid and a type of antimitotic agent." @default.
- NCIT_C1395 NCIT_P329 "40449" @default.
- NCIT_C1395 NCIT_P330 "40449" @default.
- NCIT_C1395 NCIT_P350 "C45H54N4O8.2C4H6O6" @default.
- NCIT_C1395 NCIT_P366 "Vinorelbine_Ditartrate" @default.
- NCIT_C1395 NCIT_P368 "CHEBI:32296" @default.
- NCIT_C1395 NCIT_P375 "Vinorelbine Tartrate" @default.
- NCIT_C1395 NCIT_P399 "40449" @default.
- NCIT_C1395 NCIT_R124 NCIT_C17828 @default.
- NCIT_C1395 NCIT_R124 NCIT_C20480 @default.
- NCIT_C1395 NCIT_R124 NCIT_C40795 @default.
- NCIT_C1395 NCIT_R124 NCIT_C40798 @default.
- NCIT_C1395 normalizedInformationContent "81.653330900245635" @default.
- NCIT_C1395 referenceCount "16" @default.
- NCIT_C1395 hasExactSynonym "Biovelbin" @default.
- NCIT_C1395 hasExactSynonym "Eunades" @default.
- NCIT_C1395 hasExactSynonym "KW-2307" @default.
- NCIT_C1395 hasExactSynonym "NVB" @default.
- NCIT_C1395 hasExactSynonym "Navelbine Ditartrate" @default.
- NCIT_C1395 hasExactSynonym "Navelbine ditartrate" @default.
- NCIT_C1395 hasExactSynonym "Navelbine" @default.
- NCIT_C1395 hasExactSynonym "VINORELBINE TARTRATE" @default.
- NCIT_C1395 hasExactSynonym "Vinorelbine Ditartrate" @default.
- NCIT_C1395 hasExactSynonym "Vinorelbine Tartrate" @default.
- NCIT_C1395 hasExactSynonym "vinorelbine tartrate" @default.
- NCIT_C1395 inSubset NCIT_C116977 @default.
- NCIT_C1395 inSubset NCIT_C116978 @default.
- NCIT_C1395 inSubset NCIT_C128784 @default.
- NCIT_C1395 inSubset NCIT_C157711 @default.
- NCIT_C1395 inSubset NCIT_C157712 @default.
- NCIT_C1395 inSubset NCIT_C176424 @default.
- NCIT_C1395 inSubset NCIT_C177537 @default.
- NCIT_C1395 inSubset NCIT_C63923 @default.
- NCIT_C1395 type Class @default.
- NCIT_C1395 isDefinedBy ncit.owl @default.
- NCIT_C1395 label "Vinorelbine Tartrate" @default.
- NCIT_C1395 subClassOf NCIT_C1395 @default.
- NCIT_C1395 subClassOf NCIT_C186664 @default.
- NCIT_C1395 subClassOf NCIT_C1907 @default.
- NCIT_C1395 subClassOf NCIT_C1908 @default.
- NCIT_C1395 subClassOf NCIT_C1909 @default.
- NCIT_C1395 subClassOf NCIT_C1913 @default.
- NCIT_C1395 subClassOf NCIT_C1916 @default.
- NCIT_C1395 subClassOf NCIT_C1931 @default.
- NCIT_C1395 subClassOf NCIT_C221 @default.
- NCIT_C1395 subClassOf NCIT_C25974 @default.
- NCIT_C1395 subClassOf NCIT_C273 @default.
- NCIT_C1395 subClassOf NCIT_C274 @default.
- NCIT_C1395 subClassOf NCIT_C67422 @default.
- NCIT_C1395 subClassOf NCIT_C718 @default.
- NCIT_C1395 subClassOf NCIT_C932 @default.