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- NCIT_C139551 IAO_0000115 "A neuroattenuated, replication-competent, recombinant and genetically-engineered herpes simplex virus type 1 (HSV-1), with potential oncolytic and immunostimulating activities. In rQNestin34.5v.2, the UL39 gene encoding for the viral ribonucleotide reductase large subunit infected cell protein 6 (ICP6) and both endogenous copies of the gamma34.5 gene that encodes for the RL1 neurovirulence protein infected cell protein 34.5 (ICP34.5), which is needed for robust viral growth in an infected cell, are deleted, and one copy of the gamma34.5 gene is reinserted under control of a nestin promoter, which is selectively activated in gliomas. Upon intratumoral administration, oncolytic HSV-1 rQNestin34.5v.2 preferentially infects and replicates within the rapidly dividing, glioma cells, thereby directly lysing tumor cells. The released virus particles, in turn, infect and replicate in neighboring tumor cells, thereby further killing tumor cells. rQNestin34.5v.2 also elicits a tumor-specific systemic immune and cytotoxic T-lymphocyte (CTL) response, thereby killing nearby non-infected tumor cells. By inactivating UL39, viral ribonucleotide reductase activity is disrupted, resulting in the inhibition of nucleotide metabolism and viral DNA synthesis in non-dividing, healthy cells but not in dividing cells. Glioma-selective expression of ICP34.5 imparts tumor selectivity by preventing replication in healthy cells." @default.
- NCIT_C139551 NCIT_A32 NCIT_C1909 @default.
- NCIT_C139551 NCIT_NHC0 "C139551" @default.
- NCIT_C139551 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C139551 NCIT_P106 "Virus" @default.
- NCIT_C139551 NCIT_P107 "Oncolytic HSV-1 rQNestin34.5v.2" @default.
- NCIT_C139551 NCIT_P108 "Oncolytic HSV-1 rQNestin34.5v.2" @default.
- NCIT_C139551 NCIT_P208 "CL526908" @default.
- NCIT_C139551 NCIT_P322 "CTRP" @default.
- NCIT_C139551 NCIT_P322 "GDC" @default.
- NCIT_C139551 NCIT_P329 "791103" @default.
- NCIT_C139551 NCIT_P330 "791103" @default.
- NCIT_C139551 NCIT_P375 "Oncolytic HSV-1 rQNestin34.5v.2" @default.
- NCIT_C139551 NCIT_P399 "791103" @default.
- NCIT_C139551 normalizedInformationContent "100" @default.
- NCIT_C139551 referenceCount "1" @default.
- NCIT_C139551 hasExactSynonym "Genetically Engineered HSV-1 Virus rQNestin34.5v.2" @default.
- NCIT_C139551 hasExactSynonym "Oncolytic HSV-1 rQNestin34.5v.2" @default.
- NCIT_C139551 hasExactSynonym "Oncolytic rQNestin34.5v.2 HSV Virus" @default.
- NCIT_C139551 hasExactSynonym "Oncolytic rQNestin34.5v.2" @default.
- NCIT_C139551 hasExactSynonym "rQNestin34.5v.2" @default.
- NCIT_C139551 inSubset NCIT_C116977 @default.
- NCIT_C139551 inSubset NCIT_C116978 @default.
- NCIT_C139551 inSubset NCIT_C128784 @default.
- NCIT_C139551 inSubset NCIT_C157711 @default.
- NCIT_C139551 inSubset NCIT_C157712 @default.
- NCIT_C139551 inSubset NCIT_C176424 @default.
- NCIT_C139551 inSubset NCIT_C177537 @default.
- NCIT_C139551 type Class @default.
- NCIT_C139551 isDefinedBy ncit.owl @default.
- NCIT_C139551 label "Oncolytic HSV-1 rQNestin34.5v.2" @default.
- NCIT_C139551 subClassOf NCIT_C129821 @default.
- NCIT_C139551 subClassOf NCIT_C139551 @default.
- NCIT_C139551 subClassOf NCIT_C1908 @default.
- NCIT_C139551 subClassOf NCIT_C1909 @default.
- NCIT_C139551 subClassOf NCIT_C274 @default.
- NCIT_C139551 subClassOf NCIT_C307 @default.
- NCIT_C139551 subClassOf NCIT_C717 @default.