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- NCIT_C139756 IAO_0000115 "The sulfate ester form of isavuconazonium, a prodrug of the triazole antifungal agent isavuconazole, with broad-spectrum antifungal activity. Upon administration, isavuconazonium sulfate is hydrolyzed by plasma esterases to yield the active moiety isavuconazole. Isavuconazole binds to and inhibits the fungal cytochrome P450 family enzyme lanosterol 14-alpha-demethylase (CYP51), which catalyzes the demethylation of lanosterol to yield ergosterol, an important component of the fungal cell membrane. Inhibition of CYP51 leads to a decrease in fungal ergosterol production and disrupts synthesis of the fungal cell membrane, which decreases membrane integrity, increases cell membrane permeability and promotes the loss of essential intracellular elements. This results in fungal cell lysis and death." @default.
- NCIT_C139756 NCIT_NHC0 "C139756" @default.
- NCIT_C139756 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C139756 NCIT_P107 "Isavuconazonium Sulfate" @default.
- NCIT_C139756 NCIT_P108 "Isavuconazonium Sulfate" @default.
- NCIT_C139756 NCIT_P207 "C4018470" @default.
- NCIT_C139756 NCIT_P210 "946075-13-4" @default.
- NCIT_C139756 NCIT_P319 "31Q44514JV" @default.
- NCIT_C139756 NCIT_P322 "CTRP" @default.
- NCIT_C139756 NCIT_P322 "FDA" @default.
- NCIT_C139756 NCIT_P329 "794083" @default.
- NCIT_C139756 NCIT_P330 "794083" @default.
- NCIT_C139756 NCIT_P399 "794083" @default.
- NCIT_C139756 normalizedInformationContent "100" @default.
- NCIT_C139756 referenceCount "1" @default.
- NCIT_C139756 hasExactSynonym "1-((2R,3R)-3-(4-(4-Cyanophenyl)-1,3-thiazol-2-yl)-2-(2,5-difluorophenyl)-2-hydroxybutyl)-4-((1RS)-1-((methyl(3-((((methylamino)acetyl)oxy)methyl)pyridin-2-yl)carbamoyl)oxy)ethyl)-1H-1,2,4-triazol-4-ium Monosulfate" @default.
- NCIT_C139756 hasExactSynonym "BAL8557-002" @default.
- NCIT_C139756 hasExactSynonym "Cresemba" @default.
- NCIT_C139756 hasExactSynonym "Glycine, N-methyl-, (2-(((1-(1-((2R,3R)-3-(4-(4-cyanophenyl)-2-thiazolyl)-2-(2,5-difluorophenyl)-2-hydroxybutyl)-4H-1,2,4-triazolium-4-yl)ethoxy)carbonyl)methylamino)-3-pyridinyl)methyl Ester, Sulfate (1:1)" @default.
- NCIT_C139756 hasExactSynonym "ISAVUCONAZONIUM SULFATE" @default.
- NCIT_C139756 hasExactSynonym "Isavuconazonium Sulfate" @default.
- NCIT_C139756 inSubset NCIT_C116977 @default.
- NCIT_C139756 inSubset NCIT_C116978 @default.
- NCIT_C139756 inSubset NCIT_C176424 @default.
- NCIT_C139756 inSubset NCIT_C63923 @default.
- NCIT_C139756 type Class @default.
- NCIT_C139756 isDefinedBy ncit.owl @default.
- NCIT_C139756 label "Isavuconazonium Sulfate" @default.
- NCIT_C139756 subClassOf NCIT_C139756 @default.
- NCIT_C139756 subClassOf NCIT_C1908 @default.
- NCIT_C139756 subClassOf NCIT_C1909 @default.
- NCIT_C139756 subClassOf NCIT_C254 @default.
- NCIT_C139756 subClassOf NCIT_C514 @default.