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- NCIT_C139800 IAO_0000115 "An antibody-drug conjugate (ADC) consisting of an engineered version of the humanized monoclonal anti-human epidermal growth factor receptor 2 (HER2) immunoglobulin G1 (IgG1) trastuzumab that is site-specifically conjugated, via a cleavable linker, to the cytotoxic, DNA cross-linking pyrrolobenzodiazepine (PBD) dimer-based drug tesirine, which targets DNA minor grooves, with potential antineoplastic activity. Upon administration, the trastuzumab moiety of trastuzumab/tesirine ADC ADCT-502 targets the cell surface antigen HER2, which is expressed on various cancer cells. Upon antibody/antigen binding, internalization of the ADC and cleavage of the linker, the cytotoxic PBD moiety is released. The imine groups of tesirine bind to the N2 positions of guanines on opposite strands of DNA. This induces interstrand cross-links in the minor groove of DNA, inhibits DNA replication, leads to G2/M cell cycle arrest, induces cell death and inhibits the proliferation of HER2-overexpressing tumor cells. The tumor-associated antigen (TAA) HER2 is expressed by various solid tumors and is associated with a poor prognosis." @default.
- NCIT_C139800 NCIT_A32 NCIT_C1909 @default.
- NCIT_C139800 NCIT_A7 NCIT_C17319 @default.
- NCIT_C139800 NCIT_NHC0 "C139800" @default.
- NCIT_C139800 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C139800 NCIT_P107 "Trastuzumab/Tesirine Antibody-drug Conjugate ADCT-502" @default.
- NCIT_C139800 NCIT_P108 "Trastuzumab/Tesirine Antibody-drug Conjugate ADCT-502" @default.
- NCIT_C139800 NCIT_P208 "CL537974" @default.
- NCIT_C139800 NCIT_P322 "CTRP" @default.
- NCIT_C139800 NCIT_P322 "GDC" @default.
- NCIT_C139800 NCIT_P329 "791110" @default.
- NCIT_C139800 NCIT_P330 "791110" @default.
- NCIT_C139800 NCIT_P375 "Trastuzumab/Tesirine Antibody-drug Conjugate ADCT-502" @default.
- NCIT_C139800 NCIT_P399 "791110" @default.
- NCIT_C139800 normalizedInformationContent "100" @default.
- NCIT_C139800 referenceCount "1" @default.
- NCIT_C139800 hasExactSynonym "ADC ADCT-502" @default.
- NCIT_C139800 hasExactSynonym "ADCT 502" @default.
- NCIT_C139800 hasExactSynonym "ADCT-502" @default.
- NCIT_C139800 hasExactSynonym "ADCT502" @default.
- NCIT_C139800 hasExactSynonym "Anti-HER2/PBD ADC ADCT 502" @default.
- NCIT_C139800 hasExactSynonym "Trastuzumab/Tesirine Antibody-drug Conjugate ADCT-502" @default.
- NCIT_C139800 inSubset NCIT_C116977 @default.
- NCIT_C139800 inSubset NCIT_C116978 @default.
- NCIT_C139800 inSubset NCIT_C128784 @default.
- NCIT_C139800 inSubset NCIT_C157711 @default.
- NCIT_C139800 inSubset NCIT_C157712 @default.
- NCIT_C139800 inSubset NCIT_C176424 @default.
- NCIT_C139800 inSubset NCIT_C177537 @default.
- NCIT_C139800 type Class @default.
- NCIT_C139800 isDefinedBy ncit.owl @default.
- NCIT_C139800 label "Trastuzumab/Tesirine Antibody-drug Conjugate ADCT-502" @default.
- NCIT_C139800 subClassOf NCIT_C129821 @default.
- NCIT_C139800 subClassOf NCIT_C129823 @default.
- NCIT_C139800 subClassOf NCIT_C139800 @default.
- NCIT_C139800 subClassOf NCIT_C1512 @default.
- NCIT_C139800 subClassOf NCIT_C155712 @default.
- NCIT_C139800 subClassOf NCIT_C163758 @default.
- NCIT_C139800 subClassOf NCIT_C163760 @default.
- NCIT_C139800 subClassOf NCIT_C1908 @default.
- NCIT_C139800 subClassOf NCIT_C1909 @default.
- NCIT_C139800 subClassOf NCIT_C274 @default.
- NCIT_C139800 subClassOf NCIT_C307 @default.
- NCIT_C139800 subClassOf NCIT_C308 @default.