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- NCIT_C140353 IAO_0000115 "A radioimmunoconjugate containing daratumumab, a human immunoglobulin G1 kappa (IgG1k) monoclonal antibody directed against the cell surface glycoprotein CD38, conjugated with the bifunctional, macrocyclic chelating agent tetra-azacyclododecanetetra-acetic acid (DOTA), and labeled with the radioisotope copper Cu 64, with potential diagnostic properties upon positron emission tomography (PET) imaging. The monoclonal antibody moiety of copper Cu 64-DOTA-daratumumab specifically targets and binds to cell surface antigen CD38. Upon binding, the radioisotope moiety may be detected using PET, thereby allowing the imaging and quantification of CD38-expressing tumor cells. CD38, a cell surface glycoprotein, is expressed on various hematopoietic cells and is overexpressed on multiple myeloma (MM) cells." @default.
- NCIT_C140353 NCIT_A7 NCIT_C84323 @default.
- NCIT_C140353 NCIT_NHC0 "C140353" @default.
- NCIT_C140353 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C140353 NCIT_P107 "Copper 64 Cu-DOTA-daratumumab" @default.
- NCIT_C140353 NCIT_P108 "Copper 64 Cu-DOTA-daratumumab" @default.
- NCIT_C140353 NCIT_P208 "CL538419" @default.
- NCIT_C140353 NCIT_P322 "CTRP" @default.
- NCIT_C140353 NCIT_P329 "791270" @default.
- NCIT_C140353 NCIT_P330 "791270" @default.
- NCIT_C140353 NCIT_P399 "791270" @default.
- NCIT_C140353 normalizedInformationContent "100" @default.
- NCIT_C140353 referenceCount "1" @default.
- NCIT_C140353 hasExactSynonym "64Cu-DOTA-daratumumab" @default.
- NCIT_C140353 hasExactSynonym "Copper 64 Cu-DOTA-daratumumab" @default.
- NCIT_C140353 hasExactSynonym "Copper Cu 64 Daratumumab" @default.
- NCIT_C140353 inSubset NCIT_C116977 @default.
- NCIT_C140353 inSubset NCIT_C116978 @default.
- NCIT_C140353 inSubset NCIT_C176424 @default.
- NCIT_C140353 type Class @default.
- NCIT_C140353 isDefinedBy ncit.owl @default.
- NCIT_C140353 label "Copper 64 Cu-DOTA-daratumumab" @default.
- NCIT_C140353 subClassOf NCIT_C140353 @default.
- NCIT_C140353 subClassOf NCIT_C1446 @default.
- NCIT_C140353 subClassOf NCIT_C1511 @default.
- NCIT_C140353 subClassOf NCIT_C1512 @default.
- NCIT_C140353 subClassOf NCIT_C1908 @default.
- NCIT_C140353 subClassOf NCIT_C1909 @default.
- NCIT_C140353 subClassOf NCIT_C2124 @default.
- NCIT_C140353 subClassOf NCIT_C307 @default.
- NCIT_C140353 subClassOf NCIT_C308 @default.