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- NCIT_C140551 IAO_0000115 "A second generation rexinoid and agonist of retinoid X receptor (RXR), with potential antineoplastic, neuroprotective, immunoregulatory, and disease-modifying activities. Upon administration, IRX4204 specifically binds to and activates RXRs, thereby activating RXR-mediated signaling pathways and inducing changes in gene expression that lead to cell differentiation. In responsive cancer cells, IRX4204 induces cell differentiation, decreases cell proliferation, and induces apoptosis, which leads to cancer regression. IRX4204 enhances the differentiation of CD4-positive T lymphocytes into inducible regulatory T cells (iTreg) and suppresses the development of inflammatory T helper 17 (Th17) cells. In addition, IRX4204 is able to cross the blood-brain barrier (BBB) and induces the differentiation of oligodendrocyte precursor cells (OPCs) into oligodendrocytes, promotes repair of myelin, and enhances the survival of dopaminergic neurons." @default.
- NCIT_C140551 NCIT_NHC0 "C140551" @default.
- NCIT_C140551 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C140551 NCIT_P108 "Retinoid X Receptor Agonist IRX4204" @default.
- NCIT_C140551 NCIT_P208 "CL538619" @default.
- NCIT_C140551 NCIT_P329 "791112" @default.
- NCIT_C140551 NCIT_P330 "791112" @default.
- NCIT_C140551 NCIT_P399 "791112" @default.
- NCIT_C140551 normalizedInformationContent "100" @default.
- NCIT_C140551 referenceCount "1" @default.
- NCIT_C140551 hasExactSynonym "AGN194204" @default.
- NCIT_C140551 hasExactSynonym "IRX 4204" @default.
- NCIT_C140551 hasExactSynonym "IRX-4204" @default.
- NCIT_C140551 hasExactSynonym "IRX4204" @default.
- NCIT_C140551 hasExactSynonym "RXR Agonist IRX4204" @default.
- NCIT_C140551 hasExactSynonym "Retinoid X Receptor Agonist IRX4204" @default.
- NCIT_C140551 inSubset NCIT_C176424 @default.
- NCIT_C140551 type Class @default.
- NCIT_C140551 isDefinedBy ncit.owl @default.
- NCIT_C140551 label "Retinoid X Receptor Agonist IRX4204" @default.
- NCIT_C140551 subClassOf NCIT_C129820 @default.
- NCIT_C140551 subClassOf NCIT_C140551 @default.
- NCIT_C140551 subClassOf NCIT_C163758 @default.
- NCIT_C140551 subClassOf NCIT_C1908 @default.
- NCIT_C140551 subClassOf NCIT_C1909 @default.
- NCIT_C140551 subClassOf NCIT_C1934 @default.
- NCIT_C140551 subClassOf NCIT_C2122 @default.
- NCIT_C140551 subClassOf NCIT_C274 @default.
- NCIT_C140551 subClassOf NCIT_C308 @default.
- NCIT_C140551 subClassOf NCIT_C804 @default.