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- NCIT_C14096 IAO_0000115 "The Zinc Finger Domain is found in many proteins that bind nucleic acids, typically DNA binding transcription factors. There are several classes of Zn finger proteins. Some bind Zn with only Cys residues (e.g., nuclear receptor superfamily) while others coordinate Zn with Cys and His residues. In the 25-amino acid C2H2 type motif, Zn2+ is held between a pair of anti-parallel beta strands and a single alpha helix by a pair of invariant Cys and His residues. The Cys/His type proteins generally contain repeated units and bind DNA as a monomer, while Cys/Cys proteins contain two units that bind inverted DNA repeats as homo- or heterodimers. In some Cys/Cys types the Zn ion folds the involved region into a globular structure that binds DNA." @default.
- NCIT_C14096 NCIT_NHC0 "C14096" @default.
- NCIT_C14096 NCIT_P106 "Amino Acid Sequence" @default.
- NCIT_C14096 NCIT_P108 "Zinc Finger Domain" @default.
- NCIT_C14096 NCIT_P200 "Zinc-Binding_DNA-Binding_Motif" @default.
- NCIT_C14096 NCIT_P201 "ADD-Type_Zinc-Finger" @default.
- NCIT_C14096 NCIT_P201 "C2H2_Zinc_Finger" @default.
- NCIT_C14096 NCIT_P201 "C3H1_Zinc_Finger" @default.
- NCIT_C14096 NCIT_P201 "Hormone_Receptor_DNA-Binding_Domain" @default.
- NCIT_C14096 NCIT_P201 "Zinc_Cluster" @default.
- NCIT_C14096 NCIT_P310 "Retired_Concept" @default.
- NCIT_C14096 NCIT_P366 "Zinc_Finger_Domain" @default.
- NCIT_C14096 NCIT_P98 "Thu Dec 09 17:50:44 EST 2010 - See 'Zinc-Binding_DNA-Binding_Motif'" @default.
- NCIT_C14096 normalizedInformationContent "100" @default.
- NCIT_C14096 referenceCount "1" @default.
- NCIT_C14096 hasExactSynonym "Zinc Finger Domain" @default.
- NCIT_C14096 hasExactSynonym "Zinc Finger" @default.
- NCIT_C14096 type Class @default.
- NCIT_C14096 isDefinedBy ncit.owl @default.
- NCIT_C14096 label "Zinc Finger Domain" @default.
- NCIT_C14096 subClassOf NCIT_C14096 @default.
- NCIT_C14096 subClassOf NCIT_C28428 @default.
- NCIT_C14096 subClassOf NCIT_C95421 @default.
- NCIT_C14096 deprecated "true" @default.