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- NCIT_C141074 IAO_0000115 "An inhibitor of the extracellular signal-regulated kinases (ERK) 1 and 2, with potential antineoplastic activity. Upon intravenous administration, KO-947 specifically binds to and inhibits both ERK 1 and 2, thereby preventing the activation of mitogen-activated protein kinase (MAPK)/ERK-mediated signal transduction pathways. This results in the inhibition of ERK-dependent tumor cell proliferation and survival. The MAPK/ERK pathway is often upregulated in a variety of tumor cell types and plays a key role in the proliferation, differentiation and survival of tumor cells." @default.
- NCIT_C141074 NCIT_A32 NCIT_C1909 @default.
- NCIT_C141074 NCIT_A7 NCIT_C17408 @default.
- NCIT_C141074 NCIT_A7 NCIT_C17589 @default.
- NCIT_C141074 NCIT_NHC0 "C141074" @default.
- NCIT_C141074 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C141074 NCIT_P107 "ERK1/2 Inhibitor KO-947" @default.
- NCIT_C141074 NCIT_P108 "ERK1/2 Inhibitor KO-947" @default.
- NCIT_C141074 NCIT_P208 "CL539120" @default.
- NCIT_C141074 NCIT_P322 "CTRP" @default.
- NCIT_C141074 NCIT_P322 "GDC" @default.
- NCIT_C141074 NCIT_P329 "791296" @default.
- NCIT_C141074 NCIT_P330 "791296" @default.
- NCIT_C141074 NCIT_P375 "ERK1/2 Inhibitor KO-947" @default.
- NCIT_C141074 NCIT_P399 "791296" @default.
- NCIT_C141074 normalizedInformationContent "100" @default.
- NCIT_C141074 referenceCount "1" @default.
- NCIT_C141074 hasExactSynonym "ERK Inhibitor KO-947" @default.
- NCIT_C141074 hasExactSynonym "ERK1/2 Inhibitor KO-947" @default.
- NCIT_C141074 hasExactSynonym "Extracellular Signal-regulated Kinase 1/2 Inhibitor KO-947" @default.
- NCIT_C141074 hasExactSynonym "KO 947" @default.
- NCIT_C141074 hasExactSynonym "KO-947" @default.
- NCIT_C141074 hasExactSynonym "KO947" @default.
- NCIT_C141074 inSubset NCIT_C116977 @default.
- NCIT_C141074 inSubset NCIT_C116978 @default.
- NCIT_C141074 inSubset NCIT_C128784 @default.
- NCIT_C141074 inSubset NCIT_C157711 @default.
- NCIT_C141074 inSubset NCIT_C157712 @default.
- NCIT_C141074 inSubset NCIT_C176424 @default.
- NCIT_C141074 inSubset NCIT_C177537 @default.
- NCIT_C141074 type Class @default.
- NCIT_C141074 isDefinedBy ncit.owl @default.
- NCIT_C141074 label "ERK1/2 Inhibitor KO-947" @default.
- NCIT_C141074 subClassOf NCIT_C129824 @default.
- NCIT_C141074 subClassOf NCIT_C129825 @default.
- NCIT_C141074 subClassOf NCIT_C1404 @default.
- NCIT_C141074 subClassOf NCIT_C141074 @default.
- NCIT_C141074 subClassOf NCIT_C174048 @default.
- NCIT_C141074 subClassOf NCIT_C1908 @default.
- NCIT_C141074 subClassOf NCIT_C1909 @default.
- NCIT_C141074 subClassOf NCIT_C2189 @default.
- NCIT_C141074 subClassOf NCIT_C274 @default.
- NCIT_C141074 subClassOf NCIT_C471 @default.
- NCIT_C141074 subClassOf NCIT_C61074 @default.