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- NCIT_C14111 IAO_0000115 "WD40 Repeats are found in signal transduction, mRNA processing, cytoskeletal assembly, and cell cycle proteins; none are catalytic. G-beta is the prototypic WD40 protein. WD-40 proteins contain 5-8 repeats of about 40 residues, with a central Trp-Asp (WD) motif. The repeats may span the entire protein or make up either terminal or the central section. WD40 domains serve as a platform to which proteins stably or reversibly bind; some may recognize phosphoSer and -Thr peptides. The repeat forms a closed ring propeller with seven blades each composed of a four-stranded anti-parallel b-sheet. Each repeat forms the first three strands of one blade and the last strand in the next blade. The last C-terminal repeat completes the blade of the first repeat. Residues on the propeller top surface likely coordinate interactions with other proteins or ligands." @default.
- NCIT_C14111 NCIT_NHC0 "C14111" @default.
- NCIT_C14111 NCIT_P106 "Amino Acid Sequence" @default.
- NCIT_C14111 NCIT_P108 "WD Repeat" @default.
- NCIT_C14111 NCIT_P207 "C1520109" @default.
- NCIT_C14111 NCIT_P366 "WD_Repeat" @default.
- NCIT_C14111 normalizedInformationContent "73.604245822873736" @default.
- NCIT_C14111 referenceCount "54" @default.
- NCIT_C14111 hasExactSynonym "G-Beta Repeat" @default.
- NCIT_C14111 hasExactSynonym "Trp-Asp Repeat" @default.
- NCIT_C14111 hasExactSynonym "Tryptophan-Aspartate Repeat" @default.
- NCIT_C14111 hasExactSynonym "WD Domain" @default.
- NCIT_C14111 hasExactSynonym "WD Repeat" @default.
- NCIT_C14111 hasExactSynonym "WD40 Domain" @default.
- NCIT_C14111 type Class @default.
- NCIT_C14111 isDefinedBy ncit.owl @default.
- NCIT_C14111 label "WD Repeat" @default.
- NCIT_C14111 subClassOf NCIT_C12219 @default.
- NCIT_C14111 subClassOf NCIT_C13303 @default.
- NCIT_C14111 subClassOf NCIT_C13379 @default.
- NCIT_C14111 subClassOf NCIT_C13426 @default.
- NCIT_C14111 subClassOf NCIT_C13671 @default.
- NCIT_C14111 subClassOf NCIT_C14111 @default.
- NCIT_C14111 subClassOf NCIT_C14134 @default.
- NCIT_C14111 subClassOf NCIT_C21599 @default.