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- NCIT_C141420 IAO_0000115 "A proprietary antibody-drug conjugate (ADC) composed of a monoclonal antibody against human epidermal growth factor receptor 2 (HER2) site-specifically linked, via a protease cleavable linker, to an analog of dolastatin 10, Auristatin-0101, with potential antineoplastic activity. Upon administration, anti-HER2-vc0101 ADC PF-06804103 targets HER2 expressed on tumor cells. Upon binding, internalization and cleavage, Auristatin-0101 binds to tubulin and inhibits its polymerization, resulting in G2/M phase arrest and apoptosis of HER2-expressing tumor cells. HER2, a tumor-associated antigen (TAA), is overexpressed on a variety of cancer cells." @default.
- NCIT_C141420 NCIT_A32 NCIT_C1909 @default.
- NCIT_C141420 NCIT_A7 NCIT_C17319 @default.
- NCIT_C141420 NCIT_NHC0 "C141420" @default.
- NCIT_C141420 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C141420 NCIT_P107 "Anti-HER2-vc0101 ADC PF-06804103" @default.
- NCIT_C141420 NCIT_P108 "Anti-HER2-vc0101 ADC PF-06804103" @default.
- NCIT_C141420 NCIT_P208 "CL539508" @default.
- NCIT_C141420 NCIT_P322 "CTRP" @default.
- NCIT_C141420 NCIT_P322 "GDC" @default.
- NCIT_C141420 NCIT_P329 "791410" @default.
- NCIT_C141420 NCIT_P330 "791410" @default.
- NCIT_C141420 NCIT_P375 "Anti-HER2-vc0101 ADC PF-06804103" @default.
- NCIT_C141420 NCIT_P399 "791410" @default.
- NCIT_C141420 normalizedInformationContent "100" @default.
- NCIT_C141420 referenceCount "1" @default.
- NCIT_C141420 hasExactSynonym "Anti-HER2-vc0101 ADC PF-06804103" @default.
- NCIT_C141420 hasExactSynonym "Anti-HER2-vcAur0101 ADC PF-06804103" @default.
- NCIT_C141420 hasExactSynonym "Anti-NG-HER2 ADC PF-06804103" @default.
- NCIT_C141420 hasExactSynonym "Anti-NG-Her2-vc0101 ADC PF-06804103" @default.
- NCIT_C141420 hasExactSynonym "Antibody-drug Conjugate PF-06804103" @default.
- NCIT_C141420 hasExactSynonym "PF 06804103" @default.
- NCIT_C141420 hasExactSynonym "PF-06804103" @default.
- NCIT_C141420 hasExactSynonym "PF06804103" @default.
- NCIT_C141420 inSubset NCIT_C116977 @default.
- NCIT_C141420 inSubset NCIT_C116978 @default.
- NCIT_C141420 inSubset NCIT_C128784 @default.
- NCIT_C141420 inSubset NCIT_C157711 @default.
- NCIT_C141420 inSubset NCIT_C157712 @default.
- NCIT_C141420 inSubset NCIT_C176424 @default.
- NCIT_C141420 inSubset NCIT_C177537 @default.
- NCIT_C141420 type Class @default.
- NCIT_C141420 isDefinedBy ncit.owl @default.
- NCIT_C141420 label "Anti-HER2-vc0101 ADC PF-06804103" @default.
- NCIT_C141420 subClassOf NCIT_C129821 @default.
- NCIT_C141420 subClassOf NCIT_C129823 @default.
- NCIT_C141420 subClassOf NCIT_C141420 @default.
- NCIT_C141420 subClassOf NCIT_C1512 @default.
- NCIT_C141420 subClassOf NCIT_C155712 @default.
- NCIT_C141420 subClassOf NCIT_C163758 @default.
- NCIT_C141420 subClassOf NCIT_C163760 @default.
- NCIT_C141420 subClassOf NCIT_C1908 @default.
- NCIT_C141420 subClassOf NCIT_C1909 @default.
- NCIT_C141420 subClassOf NCIT_C274 @default.
- NCIT_C141420 subClassOf NCIT_C307 @default.
- NCIT_C141420 subClassOf NCIT_C308 @default.