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- NCIT_C141421 IAO_0000115 "A fully human, immunoglobulin G4 (IgG4) monoclonal antibody targeting the co-inhibitory molecule and immune checkpoint inhibitor T-cell immunoreceptor with Ig and immunoreceptor tyrosine-based inhibitory motif (ITIM) domains (TIGIT), with potential immune checkpoint inhibitory and immunostimulating activities. Upon administration, anti-TIGIT monoclonal antibody ASP8374 targets and binds to TIGIT expressed on various immune cells, particularly on tumor-infiltrating lymphocytes (TILs), thereby preventing the interaction of TIGIT with its ligands CD112 (nectin-2; poliovirus receptor related-2; PRR2; PVRL2) and CD155 (poliovirus receptor; PVR; nectin-like protein 5; NECL-5). This enhances the interaction of CD112 and CD155 with the costimulatory receptor CD226 (DNAX Accessory molecule-1; DNAM-1), which is expressed on immune cells, such as natural killer (NK) cells and CD8+ T-cells. This leads to CD226 dimerization and CD226-mediated signaling and activates the immune system to exert a T-cell-mediated immune response against cancer cells. TIGIT, a member of the Ig super family (IgSF) and an immune inhibitory receptor, plays a key role in the suppression of T-cell proliferation and activation; it is involved in tumor cell immune evasion, and the inhibition of antiviral immune responses." @default.
- NCIT_C141421 NCIT_A32 NCIT_C1909 @default.
- NCIT_C141421 NCIT_A7 NCIT_C126125 @default.
- NCIT_C141421 NCIT_NHC0 "C141421" @default.
- NCIT_C141421 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C141421 NCIT_P107 "Anti-TIGIT Monoclonal Antibody ASP8374" @default.
- NCIT_C141421 NCIT_P108 "Anti-TIGIT Monoclonal Antibody ASP8374" @default.
- NCIT_C141421 NCIT_P208 "CL539507" @default.
- NCIT_C141421 NCIT_P319 "TB50XV90MW" @default.
- NCIT_C141421 NCIT_P322 "CTRP" @default.
- NCIT_C141421 NCIT_P322 "FDA" @default.
- NCIT_C141421 NCIT_P322 "GDC" @default.
- NCIT_C141421 NCIT_P329 "791403" @default.
- NCIT_C141421 NCIT_P330 "791403" @default.
- NCIT_C141421 NCIT_P375 "Immune Checkpoint Inhibitor ASP8374" @default.
- NCIT_C141421 NCIT_P399 "791403" @default.
- NCIT_C141421 NCIT_R124 NCIT_C17710 @default.
- NCIT_C141421 NCIT_R124 NCIT_C17828 @default.
- NCIT_C141421 NCIT_R124 NCIT_C18219 @default.
- NCIT_C141421 NCIT_R124 NCIT_C19986 @default.
- NCIT_C141421 NCIT_R124 NCIT_C40474 @default.
- NCIT_C141421 normalizedInformationContent "100" @default.
- NCIT_C141421 referenceCount "1" @default.
- NCIT_C141421 hasExactSynonym "ASP 8374" @default.
- NCIT_C141421 hasExactSynonym "ASP-8374" @default.
- NCIT_C141421 hasExactSynonym "ASP8374" @default.
- NCIT_C141421 hasExactSynonym "Anti-TIGIT Monoclonal Antibody ASP8374" @default.
- NCIT_C141421 hasExactSynonym "PTZ-201" @default.
- NCIT_C141421 inSubset NCIT_C116977 @default.
- NCIT_C141421 inSubset NCIT_C116978 @default.
- NCIT_C141421 inSubset NCIT_C128784 @default.
- NCIT_C141421 inSubset NCIT_C157711 @default.
- NCIT_C141421 inSubset NCIT_C157712 @default.
- NCIT_C141421 inSubset NCIT_C176424 @default.
- NCIT_C141421 inSubset NCIT_C177537 @default.
- NCIT_C141421 inSubset NCIT_C63923 @default.
- NCIT_C141421 type Class @default.
- NCIT_C141421 isDefinedBy ncit.owl @default.
- NCIT_C141421 label "Anti-TIGIT Monoclonal Antibody ASP8374" @default.
- NCIT_C141421 subClassOf NCIT_C134787 @default.
- NCIT_C141421 subClassOf NCIT_C141144 @default.
- NCIT_C141421 subClassOf NCIT_C141421 @default.
- NCIT_C141421 subClassOf NCIT_C1908 @default.
- NCIT_C141421 subClassOf NCIT_C1909 @default.
- NCIT_C141421 subClassOf NCIT_C20401 @default.
- NCIT_C141421 subClassOf NCIT_C307 @default.
- NCIT_C141421 subClassOf NCIT_C308 @default.