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- NCIT_C141427 IAO_0000115 "An inhibitor of Bruton's tyrosine kinase (BTK) with potential antineoplastic activity. Upon administration, evobrutinib inhibits the activity of BTK and prevents the activation of the B-cell antigen receptor (BCR) signaling pathway. This prevents both B-cell activation and BTK-mediated activation of downstream survival pathways, which leads to the inhibition of the growth of malignant B-cells that overexpress BTK. BTK, a member of the Src-related BTK/Tec family of cytoplasmic tyrosine kinases, is overexpressed in B-cell malignancies; it plays an important role in B-lymphocyte development, activation, signaling, proliferation and survival." @default.
- NCIT_C141427 NCIT_NHC0 "C141427" @default.
- NCIT_C141427 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C141427 NCIT_P108 "Evobrutinib" @default.
- NCIT_C141427 NCIT_P208 "CL539517" @default.
- NCIT_C141427 NCIT_P210 "1415823-73-2" @default.
- NCIT_C141427 NCIT_P319 "ZA45457L1K" @default.
- NCIT_C141427 NCIT_P322 "FDA" @default.
- NCIT_C141427 normalizedInformationContent "100" @default.
- NCIT_C141427 referenceCount "1" @default.
- NCIT_C141427 hasExactSynonym "1-(4-((6-Amino-5-(4-phenoxy-phenyl)-pyrimidin-4-ylamino)-methyl)-piperidin-1-yl)-propenone" @default.
- NCIT_C141427 hasExactSynonym "EVOBRUTINIB" @default.
- NCIT_C141427 hasExactSynonym "Evobrutinib" @default.
- NCIT_C141427 inSubset NCIT_C63923 @default.
- NCIT_C141427 type Class @default.
- NCIT_C141427 isDefinedBy ncit.owl @default.
- NCIT_C141427 label "Evobrutinib" @default.
- NCIT_C141427 subClassOf NCIT_C124801 @default.
- NCIT_C141427 subClassOf NCIT_C1404 @default.
- NCIT_C141427 subClassOf NCIT_C141427 @default.
- NCIT_C141427 subClassOf NCIT_C163758 @default.
- NCIT_C141427 subClassOf NCIT_C163774 @default.
- NCIT_C141427 subClassOf NCIT_C1908 @default.
- NCIT_C141427 subClassOf NCIT_C1909 @default.
- NCIT_C141427 subClassOf NCIT_C1967 @default.
- NCIT_C141427 subClassOf NCIT_C274 @default.
- NCIT_C141427 subClassOf NCIT_C471 @default.