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- NCIT_C141443 IAO_0000115 "The monophosphate form of PF-04217903, an orally bioavailabe, small-molecule tyrosine kinase inhibitor with potential antineoplastic activity. MET tyrosine kinase inhibitor PF-04217903 selectively binds to and inhibits c-Met, disrupting the c-Met signaling pathway, which may result in the inhibition of tumor cell growth, migration and invasion of tumor cells, and the induction of death in tumor cells expressing c-Met. The receptor tyrosine kinase c-Met, also known as hepatocyte growth factor (HGF) receptor, is overexpressed or mutated in many tumor cell types, playing an important role in tumor cell proliferation, survival, invasion, and metastasis and angiogenesis." @default.
- NCIT_C141443 NCIT_A6 NCIT_C78483 @default.
- NCIT_C141443 NCIT_NHC0 "C141443" @default.
- NCIT_C141443 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C141443 NCIT_P108 "PF-04217903 Monophosphate" @default.
- NCIT_C141443 NCIT_P208 "CL539504" @default.
- NCIT_C141443 NCIT_P210 "1159490-83-1" @default.
- NCIT_C141443 NCIT_P319 "E1E1K0PK8V" @default.
- NCIT_C141443 NCIT_P322 "FDA" @default.
- NCIT_C141443 normalizedInformationContent "100" @default.
- NCIT_C141443 referenceCount "1" @default.
- NCIT_C141443 hasExactSynonym "1H-Pyrazole-1-ethanol, 4-(1-(6-Quinolinylmethyl)-1H-1,2,3-triazolo(4,5-b)pyrazin-6-yl)-, Phosphate (1:1)" @default.
- NCIT_C141443 hasExactSynonym "PF-04217903 MONOPHOSPHATE" @default.
- NCIT_C141443 hasExactSynonym "PF-04217903 Monophosphate" @default.
- NCIT_C141443 inSubset NCIT_C63923 @default.
- NCIT_C141443 type Class @default.
- NCIT_C141443 isDefinedBy ncit.owl @default.
- NCIT_C141443 label "PF-04217903 Monophosphate" @default.
- NCIT_C141443 subClassOf NCIT_C1404 @default.
- NCIT_C141443 subClassOf NCIT_C141443 @default.
- NCIT_C141443 subClassOf NCIT_C1908 @default.
- NCIT_C141443 subClassOf NCIT_C1909 @default.
- NCIT_C141443 subClassOf NCIT_C1967 @default.
- NCIT_C141443 subClassOf NCIT_C471 @default.