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- NCIT_C141516 IAO_0000115 "The hydrochloride salt form of iberdomide, a modulator of the E3 ubiquitin ligase complex containing cereblon (CRL4-CRBN E3 ubiquitin ligase), with potential immunomodulating and pro-apoptotic activities. Upon administration, iberdomide specifically binds to the cereblon (CRBN) part of the ligase complex, thereby affecting the ubiquitin E3 ligase activity, and targeting certain substrate proteins for ubiquitination. This induces the proteasome-mediated degradation of certain transcription factors, including Ikaros (IKZF1) and Aiolos (IKZF3) which are transcriptional repressors in T-cells. This leads to a reduction of their protein levels, and the modulation of the immune system, including activation of T-lymphocytes. In addition, this leads to a downregulation of other proteins, including interferon regulatory factor 4 (IRF4), which plays a key role in the proliferation of certain cancer cell types. CRBN, the substrate recognition component of the E3 ubiquitin ligase complex, plays a key role in the ubiquitination of certain proteins." @default.
- NCIT_C141516 NCIT_A6 NCIT_C129048 @default.
- NCIT_C141516 NCIT_A7 NCIT_C104142 @default.
- NCIT_C141516 NCIT_NHC0 "C141516" @default.
- NCIT_C141516 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C141516 NCIT_P107 "Iberdomide Hydrochloride" @default.
- NCIT_C141516 NCIT_P108 "Iberdomide Hydrochloride" @default.
- NCIT_C141516 NCIT_P208 "CL539551" @default.
- NCIT_C141516 NCIT_P210 "1560678-63-8" @default.
- NCIT_C141516 NCIT_P319 "79L3645KFI" @default.
- NCIT_C141516 NCIT_P322 "CTRP" @default.
- NCIT_C141516 NCIT_P322 "FDA" @default.
- NCIT_C141516 NCIT_P399 "811342" @default.
- NCIT_C141516 normalizedInformationContent "100" @default.
- NCIT_C141516 referenceCount "1" @default.
- NCIT_C141516 hasExactSynonym "2,6-Piperidinedione, 3-(1,3-dihydro-4-((4-(4-morpholinylmethyl)phenyl)methoxy)-1-oxo-2H-isoindol-2-yl)-, Hydrochloride (1:1), (3S)-" @default.
- NCIT_C141516 hasExactSynonym "CC-220 Hydrochloride" @default.
- NCIT_C141516 hasExactSynonym "IBERDOMIDE HYDROCHLORIDE" @default.
- NCIT_C141516 hasExactSynonym "Iberdomide Hydrochloride" @default.
- NCIT_C141516 inSubset NCIT_C116977 @default.
- NCIT_C141516 inSubset NCIT_C116978 @default.
- NCIT_C141516 inSubset NCIT_C63923 @default.
- NCIT_C141516 type Class @default.
- NCIT_C141516 isDefinedBy ncit.owl @default.
- NCIT_C141516 label "Iberdomide Hydrochloride" @default.
- NCIT_C141516 subClassOf NCIT_C141516 @default.
- NCIT_C141516 subClassOf NCIT_C1908 @default.
- NCIT_C141516 subClassOf NCIT_C1909 @default.
- NCIT_C141516 subClassOf NCIT_C308 @default.