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- NCIT_C142086 IAO_0000115 "An orally available inhibitor of the protein fascin, with potential antineoplastic activity. Upon oral administration, NP-G2-044 targets and binds to fascin, thereby preventing the interaction of fascin with actin filaments, thereby preventing actin bundling and filopodia formation. By preventing actin cytoskeletal reorganization, the dynamic changes in cell shape that are necessary for tumor cell migration and invasion to occur are impaired, and tumor cell migration and metastasis are inhibited. Fascin, the main actin cross-linker protein in filopodia, is upregulated in many types of metastatic tumor cells while its expression is low or absent in normal adult epithelial cells; its expression is correlated with aggressive phenotypes, poor prognosis, and shorter survival. Filopodia, finger-like plasma membrane protrusions that are formed upon remodeling of the actin cytoskeleton, are found at a high frequency in metastatic tumor cells and their presence is correlated with tumor cell invasiveness." @default.
- NCIT_C142086 NCIT_A32 NCIT_C1909 @default.
- NCIT_C142086 NCIT_A7 NCIT_C101607 @default.
- NCIT_C142086 NCIT_NHC0 "C142086" @default.
- NCIT_C142086 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C142086 NCIT_P107 "Fascin Inhibitor NP-G2-044" @default.
- NCIT_C142086 NCIT_P108 "Fascin Inhibitor NP-G2-044" @default.
- NCIT_C142086 NCIT_P208 "CL540124" @default.
- NCIT_C142086 NCIT_P210 "1807454-59-6" @default.
- NCIT_C142086 NCIT_P319 "1ER2O3UZ4W" @default.
- NCIT_C142086 NCIT_P322 "CTRP" @default.
- NCIT_C142086 NCIT_P322 "FDA" @default.
- NCIT_C142086 NCIT_P322 "GDC" @default.
- NCIT_C142086 NCIT_P329 "793138" @default.
- NCIT_C142086 NCIT_P330 "793138" @default.
- NCIT_C142086 NCIT_P375 "Fascin Inhibitor NP-G2-044" @default.
- NCIT_C142086 NCIT_P399 "793138" @default.
- NCIT_C142086 normalizedInformationContent "100" @default.
- NCIT_C142086 referenceCount "1" @default.
- NCIT_C142086 hasExactSynonym "2-Methyl-N-(1-((4-(trifluoromethyl)phenyl)methyl)-1H-indazol-3-yl)-3-furancarboxamide" @default.
- NCIT_C142086 hasExactSynonym "Fascin Inhibitor NP-G2-044" @default.
- NCIT_C142086 hasExactSynonym "NP G2 044" @default.
- NCIT_C142086 hasExactSynonym "NP-G2-044" @default.
- NCIT_C142086 inSubset NCIT_C116977 @default.
- NCIT_C142086 inSubset NCIT_C116978 @default.
- NCIT_C142086 inSubset NCIT_C128784 @default.
- NCIT_C142086 inSubset NCIT_C157711 @default.
- NCIT_C142086 inSubset NCIT_C157712 @default.
- NCIT_C142086 inSubset NCIT_C176424 @default.
- NCIT_C142086 inSubset NCIT_C177537 @default.
- NCIT_C142086 inSubset NCIT_C63923 @default.
- NCIT_C142086 type Class @default.
- NCIT_C142086 isDefinedBy ncit.owl @default.
- NCIT_C142086 label "Fascin Inhibitor NP-G2-044" @default.
- NCIT_C142086 subClassOf NCIT_C142086 @default.
- NCIT_C142086 subClassOf NCIT_C1908 @default.
- NCIT_C142086 subClassOf NCIT_C1909 @default.
- NCIT_C142086 subClassOf NCIT_C2196 @default.
- NCIT_C142086 subClassOf NCIT_C274 @default.