Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C142139> ?p ?o ?g. }
Showing items 1 to 40 of
40
with 100 items per page.
- NCIT_C142139 IAO_0000115 "A DNA vaccine consisting of a plasmid encoding a synthetic, full-length sequence of the tumor-associated antigen (TAA) telomerase reverse transcriptase (TERT), which was derived from the consensus sequence from humans and primates and contains two immunogenic mutations (SynCon TERT), with potential immunostimulating and antineoplastic activities. Upon intramuscular administration of INO-1401 in combination with electroporation, TERT protein is expressed and activates the immune system to mount a cytotoxic T-cell (CTL) response against telomerase-expressing tumor cells, which may result in tumor cell death. TERT is the catalytic subunit of telomerase and synthesizes telomeric DNA at the chromosome ends. Telomerase prolongs the functional lifespan of cells via the restoration and maintenance of telomere length. Abnormally activated in tumorigenesis, TERT is expressed by many types of human cancer cells, but its expression is low or non-existent in normal cells." @default.
- NCIT_C142139 NCIT_A32 NCIT_C1909 @default.
- NCIT_C142139 NCIT_A7 NCIT_C17470 @default.
- NCIT_C142139 NCIT_NHC0 "C142139" @default.
- NCIT_C142139 NCIT_P106 "Nucleic Acid, Nucleoside, or Nucleotide" @default.
- NCIT_C142139 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C142139 NCIT_P107 "Synthetic hTERT DNA Vaccine INO-1401" @default.
- NCIT_C142139 NCIT_P108 "Synthetic hTERT DNA Vaccine INO-1401" @default.
- NCIT_C142139 NCIT_P208 "CL540179" @default.
- NCIT_C142139 NCIT_P322 "CTRP" @default.
- NCIT_C142139 NCIT_P322 "GDC" @default.
- NCIT_C142139 NCIT_P329 "791450" @default.
- NCIT_C142139 NCIT_P330 "791450" @default.
- NCIT_C142139 NCIT_P375 "Synthetic hTERT DNA Vaccine INO-1401" @default.
- NCIT_C142139 NCIT_P399 "791450" @default.
- NCIT_C142139 normalizedInformationContent "100" @default.
- NCIT_C142139 referenceCount "1" @default.
- NCIT_C142139 hasExactSynonym "INO-1401" @default.
- NCIT_C142139 hasExactSynonym "SynCon TERT" @default.
- NCIT_C142139 hasExactSynonym "Synthetic hTERT DNA Vaccine INO-1401" @default.
- NCIT_C142139 inSubset NCIT_C116977 @default.
- NCIT_C142139 inSubset NCIT_C116978 @default.
- NCIT_C142139 inSubset NCIT_C128784 @default.
- NCIT_C142139 inSubset NCIT_C157711 @default.
- NCIT_C142139 inSubset NCIT_C157712 @default.
- NCIT_C142139 inSubset NCIT_C176424 @default.
- NCIT_C142139 inSubset NCIT_C177537 @default.
- NCIT_C142139 type Class @default.
- NCIT_C142139 isDefinedBy ncit.owl @default.
- NCIT_C142139 label "Synthetic hTERT DNA Vaccine INO-1401" @default.
- NCIT_C142139 subClassOf NCIT_C129820 @default.
- NCIT_C142139 subClassOf NCIT_C142139 @default.
- NCIT_C142139 subClassOf NCIT_C1663 @default.
- NCIT_C142139 subClassOf NCIT_C1908 @default.
- NCIT_C142139 subClassOf NCIT_C1909 @default.
- NCIT_C142139 subClassOf NCIT_C274 @default.
- NCIT_C142139 subClassOf NCIT_C307 @default.
- NCIT_C142139 subClassOf NCIT_C308 @default.
- NCIT_C142139 subClassOf NCIT_C39619 @default.
- NCIT_C142139 subClassOf NCIT_C923 @default.