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- NCIT_C142168 IAO_0000115 "A proprietary humanized monoclonal antibody directed against the negative immunoregulatory human cell surface receptor programmed cell death 1 (PD-1), with potential immune checkpoint inhibitory and antineoplastic activities. Upon administration, retifanlimab binds to and inhibits PD-1 and its downstream signaling pathways. This may restore immune function through the activation of T-cells and cell-mediated immune responses against tumor cells. PD-1, a transmembrane protein in the immunoglobulin superfamily (IgSF) expressed on T-cells, functions as an immune checkpoint that negatively regulates T-cell activation and effector function when activated by its ligands programmed cell death ligand 1 (PD-L1) or 2 (PD-L2); it plays an important role in tumor evasion from host immunity." @default.
- NCIT_C142168 NCIT_A32 NCIT_C1909 @default.
- NCIT_C142168 NCIT_A7 NCIT_C94697 @default.
- NCIT_C142168 NCIT_NHC0 "C142168" @default.
- NCIT_C142168 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C142168 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C142168 NCIT_P107 "Retifanlimab" @default.
- NCIT_C142168 NCIT_P108 "Retifanlimab" @default.
- NCIT_C142168 NCIT_P208 "CL540160" @default.
- NCIT_C142168 NCIT_P210 "2226345-85-1" @default.
- NCIT_C142168 NCIT_P302 "metastatic or recurrent locally advanced Merkel cell carcinoma (MCC)." @default.
- NCIT_C142168 NCIT_P319 "2Y3T5IF01Z" @default.
- NCIT_C142168 NCIT_P322 "CTRP" @default.
- NCIT_C142168 NCIT_P322 "FDA" @default.
- NCIT_C142168 NCIT_P322 "GDC" @default.
- NCIT_C142168 NCIT_P329 "791453" @default.
- NCIT_C142168 NCIT_P330 "791453" @default.
- NCIT_C142168 NCIT_P375 "Anti-PD-1 Monoclonal Antibody MGA012" @default.
- NCIT_C142168 NCIT_P375 "Retifanlimab" @default.
- NCIT_C142168 NCIT_P399 "791453" @default.
- NCIT_C142168 NCIT_R124 NCIT_C17710 @default.
- NCIT_C142168 NCIT_R124 NCIT_C17828 @default.
- NCIT_C142168 NCIT_R124 NCIT_C18219 @default.
- NCIT_C142168 NCIT_R124 NCIT_C19986 @default.
- NCIT_C142168 NCIT_R124 NCIT_C40474 @default.
- NCIT_C142168 normalizedInformationContent "95.413332725061409" @default.
- NCIT_C142168 referenceCount "2" @default.
- NCIT_C142168 hasExactSynonym "INCMGA 0012" @default.
- NCIT_C142168 hasExactSynonym "INCMGA-0012" @default.
- NCIT_C142168 hasExactSynonym "INCMGA00012" @default.
- NCIT_C142168 hasExactSynonym "INCMGA0012" @default.
- NCIT_C142168 hasExactSynonym "MGA 012" @default.
- NCIT_C142168 hasExactSynonym "MGA-012" @default.
- NCIT_C142168 hasExactSynonym "MGA012" @default.
- NCIT_C142168 hasExactSynonym "RETIFANLIMAB" @default.
- NCIT_C142168 hasExactSynonym "Retifanlimab" @default.
- NCIT_C142168 hasExactSynonym "Retifanlimab-dlwr" @default.
- NCIT_C142168 hasExactSynonym "Zynyz" @default.
- NCIT_C142168 inSubset NCIT_C116977 @default.
- NCIT_C142168 inSubset NCIT_C116978 @default.
- NCIT_C142168 inSubset NCIT_C128784 @default.
- NCIT_C142168 inSubset NCIT_C157711 @default.
- NCIT_C142168 inSubset NCIT_C157712 @default.
- NCIT_C142168 inSubset NCIT_C176424 @default.
- NCIT_C142168 inSubset NCIT_C177537 @default.
- NCIT_C142168 inSubset NCIT_C63923 @default.
- NCIT_C142168 type Class @default.
- NCIT_C142168 isDefinedBy ncit.owl @default.
- NCIT_C142168 label "Retifanlimab" @default.
- NCIT_C142168 subClassOf NCIT_C124946 @default.
- NCIT_C142168 subClassOf NCIT_C128037 @default.
- NCIT_C142168 subClassOf NCIT_C129821 @default.
- NCIT_C142168 subClassOf NCIT_C129822 @default.
- NCIT_C142168 subClassOf NCIT_C141144 @default.
- NCIT_C142168 subClassOf NCIT_C142168 @default.
- NCIT_C142168 subClassOf NCIT_C143250 @default.
- NCIT_C142168 subClassOf NCIT_C163758 @default.
- NCIT_C142168 subClassOf NCIT_C1908 @default.
- NCIT_C142168 subClassOf NCIT_C1909 @default.
- NCIT_C142168 subClassOf NCIT_C20401 @default.
- NCIT_C142168 subClassOf NCIT_C274 @default.
- NCIT_C142168 subClassOf NCIT_C307 @default.
- NCIT_C142168 subClassOf NCIT_C308 @default.