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- NCIT_C142788 IAO_0000115 "The hydrochloride salt form of ivospemin, an analogue of naturally occurring polyamine (PA), with potential antineoplastic activity. Upon subcutaneous administration, ivospemin displaces endogenous PAs from PA-binding sites on the cell surface, which prevents internalization of PA. This inhibits PA-dependent cell cycle processes and results in cell cycle arrest, the induction of apoptosis, and inhibition of tumor cell proliferation. PA uptake is upregulated in various tumor types and increased levels of PA leads to enhanced tumor cell growth." @default.
- NCIT_C142788 NCIT_A32 NCIT_C1909 @default.
- NCIT_C142788 NCIT_A6 NCIT_C184886 @default.
- NCIT_C142788 NCIT_NHC0 "C142788" @default.
- NCIT_C142788 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C142788 NCIT_P107 "Ivospemin Hydrochloride" @default.
- NCIT_C142788 NCIT_P108 "Ivospemin Hydrochloride" @default.
- NCIT_C142788 NCIT_P208 "CL540733" @default.
- NCIT_C142788 NCIT_P210 "259657-09-5" @default.
- NCIT_C142788 NCIT_P319 "2RKV12BBA7" @default.
- NCIT_C142788 NCIT_P322 "CTRP" @default.
- NCIT_C142788 NCIT_P322 "FDA" @default.
- NCIT_C142788 NCIT_P322 "GDC" @default.
- NCIT_C142788 NCIT_P329 "791597" @default.
- NCIT_C142788 NCIT_P330 "791597" @default.
- NCIT_C142788 NCIT_P375 "Polyamine Analogue SBP-101" @default.
- NCIT_C142788 NCIT_P399 "791597" @default.
- NCIT_C142788 normalizedInformationContent "100" @default.
- NCIT_C142788 referenceCount "1" @default.
- NCIT_C142788 hasExactSynonym "Diethyl Dihydroxyhomospermine" @default.
- NCIT_C142788 hasExactSynonym "HO2-DEHSPM" @default.
- NCIT_C142788 hasExactSynonym "IVOSPEMIN HYDROCHLORIDE" @default.
- NCIT_C142788 hasExactSynonym "Ivospemin Hydrochloride" @default.
- NCIT_C142788 hasExactSynonym "Polyamine Analogue SBP-101" @default.
- NCIT_C142788 hasExactSynonym "SBP 101 Tetrahydrochloride" @default.
- NCIT_C142788 hasExactSynonym "SBP-101 Tetrahydrochloride" @default.
- NCIT_C142788 inSubset NCIT_C116977 @default.
- NCIT_C142788 inSubset NCIT_C116978 @default.
- NCIT_C142788 inSubset NCIT_C128784 @default.
- NCIT_C142788 inSubset NCIT_C157711 @default.
- NCIT_C142788 inSubset NCIT_C157712 @default.
- NCIT_C142788 inSubset NCIT_C176424 @default.
- NCIT_C142788 inSubset NCIT_C177537 @default.
- NCIT_C142788 inSubset NCIT_C63923 @default.
- NCIT_C142788 type Class @default.
- NCIT_C142788 isDefinedBy ncit.owl @default.
- NCIT_C142788 label "Ivospemin Hydrochloride" @default.
- NCIT_C142788 subClassOf NCIT_C142788 @default.
- NCIT_C142788 subClassOf NCIT_C186664 @default.
- NCIT_C142788 subClassOf NCIT_C1908 @default.
- NCIT_C142788 subClassOf NCIT_C1909 @default.
- NCIT_C142788 subClassOf NCIT_C274 @default.
- NCIT_C142788 subClassOf NCIT_C2842 @default.
- NCIT_C142788 subClassOf NCIT_C49109 @default.