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- NCIT_C142822 IAO_0000115 "A humanized monoclonal antibody targeting a proliferation-inducing ligand (APRIL; tumor necrosis factor ligand superfamily member 13; TNFSF13), with potential antineoplastic and immune checkpoint inhibitory activities. Upon administration, zigakibart binds to APRIL and inhibits its binding to both of its receptors, B-cell maturation antigen (BCMA; tumor necrosis factor receptor superfamily member 17; TNFRSF17) and transmembrane activator and CAML Interactor (TACI; tumor necrosis factor receptor superfamily member 13B; TNFRSF13B). This inhibits the activation of both BCMA and TACI, and their downstream signaling pathways, which prevents tumor growth, tumor cell adhesion to bone marrow cells and immune suppression. Additionally, zigakibart may reduce APRIL-induced drug resistance which occurs in some tumors. APRIL, an extracellular protein and member of the tumor necrosis factor ligand superfamily (TNFSF), is expressed by bone marrow plasma cells and myeloid cells, and overexpressed in multiple myeloma (MM), chronic lymphocytic leukemia (CLL), and colorectal carcinoma. APRIL induces immune suppression and tumor progression through the activation of BCMA- and TACI-dependent signaling pathways." @default.
- NCIT_C142822 NCIT_A32 NCIT_C1909 @default.
- NCIT_C142822 NCIT_A7 NCIT_C105969 @default.
- NCIT_C142822 NCIT_NHC0 "C142822" @default.
- NCIT_C142822 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C142822 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C142822 NCIT_P107 "Zigakibart" @default.
- NCIT_C142822 NCIT_P108 "Zigakibart" @default.
- NCIT_C142822 NCIT_P208 "CL540711" @default.
- NCIT_C142822 NCIT_P210 "2642175-46-8" @default.
- NCIT_C142822 NCIT_P319 "WM18Z62RTI" @default.
- NCIT_C142822 NCIT_P322 "CTRP" @default.
- NCIT_C142822 NCIT_P322 "FDA" @default.
- NCIT_C142822 NCIT_P322 "GDC" @default.
- NCIT_C142822 NCIT_P329 "791698" @default.
- NCIT_C142822 NCIT_P330 "791698" @default.
- NCIT_C142822 NCIT_P375 "Anti-APRIL Monoclonal Antibody BION-1301" @default.
- NCIT_C142822 NCIT_P399 "791698" @default.
- NCIT_C142822 NCIT_R124 NCIT_C17710 @default.
- NCIT_C142822 NCIT_R124 NCIT_C17828 @default.
- NCIT_C142822 NCIT_R124 NCIT_C18219 @default.
- NCIT_C142822 NCIT_R124 NCIT_C19986 @default.
- NCIT_C142822 NCIT_R124 NCIT_C40474 @default.
- NCIT_C142822 normalizedInformationContent "100" @default.
- NCIT_C142822 referenceCount "1" @default.
- NCIT_C142822 hasExactSynonym "Anti-A PRoliferation-Inducing Ligand Monoclonal Antibody BION-1301" @default.
- NCIT_C142822 hasExactSynonym "Anti-APRIL Monoclonal Antibody BION-1301" @default.
- NCIT_C142822 hasExactSynonym "Anti-TNFSF13 Monoclonal Antibody BION-1301" @default.
- NCIT_C142822 hasExactSynonym "BION-1301" @default.
- NCIT_C142822 hasExactSynonym "ZIGAKIBART" @default.
- NCIT_C142822 hasExactSynonym "Zigakibart" @default.
- NCIT_C142822 inSubset NCIT_C116977 @default.
- NCIT_C142822 inSubset NCIT_C116978 @default.
- NCIT_C142822 inSubset NCIT_C128784 @default.
- NCIT_C142822 inSubset NCIT_C157711 @default.
- NCIT_C142822 inSubset NCIT_C157712 @default.
- NCIT_C142822 inSubset NCIT_C176424 @default.
- NCIT_C142822 inSubset NCIT_C177537 @default.
- NCIT_C142822 inSubset NCIT_C63923 @default.
- NCIT_C142822 type Class @default.
- NCIT_C142822 isDefinedBy ncit.owl @default.
- NCIT_C142822 label "Zigakibart" @default.
- NCIT_C142822 subClassOf NCIT_C129821 @default.
- NCIT_C142822 subClassOf NCIT_C129822 @default.
- NCIT_C142822 subClassOf NCIT_C142822 @default.
- NCIT_C142822 subClassOf NCIT_C1908 @default.
- NCIT_C142822 subClassOf NCIT_C1909 @default.
- NCIT_C142822 subClassOf NCIT_C20401 @default.
- NCIT_C142822 subClassOf NCIT_C274 @default.
- NCIT_C142822 subClassOf NCIT_C307 @default.
- NCIT_C142822 subClassOf NCIT_C308 @default.