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- NCIT_C142831 IAO_0000115 "A proprietary orally available inhibitor of methionine aminopeptidase 2 (MetAP2), which cleaves the amino-terminal methionine residue from nascent proteins, with potential antiangiogenic and antineoplastic activities. Upon administration, MetAP2 inhibitor M8891 inhibits MetAP2 aminopeptidase activity and impairs protein synthesis, which may lead to a decrease in endothelial cell proliferation. Decreased proliferation of endothelial cells results in reductions of both angiogenesis and the growth and spread of solid tumors that are dependent on new blood vessel formation. MetAP2, a metallopeptidase, is involved in promoting protein synthesis and endothelial cell proliferation." @default.
- NCIT_C142831 NCIT_A32 NCIT_C1909 @default.
- NCIT_C142831 NCIT_A7 NCIT_C143021 @default.
- NCIT_C142831 NCIT_NHC0 "C142831" @default.
- NCIT_C142831 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C142831 NCIT_P107 "Methionine Aminopeptidase 2 Inhibitor M8891" @default.
- NCIT_C142831 NCIT_P108 "Methionine Aminopeptidase 2 Inhibitor M8891" @default.
- NCIT_C142831 NCIT_P208 "CL540704" @default.
- NCIT_C142831 NCIT_P322 "CTRP" @default.
- NCIT_C142831 NCIT_P322 "GDC" @default.
- NCIT_C142831 NCIT_P329 "791701" @default.
- NCIT_C142831 NCIT_P330 "791701" @default.
- NCIT_C142831 NCIT_P375 "Methionine Aminopeptidase 2 Inhibitor M8891" @default.
- NCIT_C142831 NCIT_P399 "791701" @default.
- NCIT_C142831 normalizedInformationContent "100" @default.
- NCIT_C142831 referenceCount "1" @default.
- NCIT_C142831 hasExactSynonym "M8891" @default.
- NCIT_C142831 hasExactSynonym "MetAP2 Inhibitor M8891" @default.
- NCIT_C142831 hasExactSynonym "Methionine Aminopeptidase 2 Inhibitor M8891" @default.
- NCIT_C142831 inSubset NCIT_C116977 @default.
- NCIT_C142831 inSubset NCIT_C116978 @default.
- NCIT_C142831 inSubset NCIT_C128784 @default.
- NCIT_C142831 inSubset NCIT_C157711 @default.
- NCIT_C142831 inSubset NCIT_C157712 @default.
- NCIT_C142831 inSubset NCIT_C176424 @default.
- NCIT_C142831 inSubset NCIT_C177537 @default.
- NCIT_C142831 type Class @default.
- NCIT_C142831 isDefinedBy ncit.owl @default.
- NCIT_C142831 label "Methionine Aminopeptidase 2 Inhibitor M8891" @default.
- NCIT_C142831 subClassOf NCIT_C129824 @default.
- NCIT_C142831 subClassOf NCIT_C129825 @default.
- NCIT_C142831 subClassOf NCIT_C142831 @default.
- NCIT_C142831 subClassOf NCIT_C1742 @default.
- NCIT_C142831 subClassOf NCIT_C1908 @default.
- NCIT_C142831 subClassOf NCIT_C1909 @default.
- NCIT_C142831 subClassOf NCIT_C2143 @default.
- NCIT_C142831 subClassOf NCIT_C2189 @default.
- NCIT_C142831 subClassOf NCIT_C274 @default.
- NCIT_C142831 subClassOf NCIT_C471 @default.
- NCIT_C142831 subClassOf NCIT_C783 @default.