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- NCIT_C142834 IAO_0000115 "A preparation of autologous human T-lymphocytes engineered to express a chimeric T-cell receptor (chimeric antigen receptor or CAR) consisting of one or more binding domains targeting the tumor-associated antigens (TAAs) CD19 and CD22 and fused to one or more co-stimulatory TCR-signaling domains, with potential immunostimulating and antineoplastic activities. Upon administration, the autologous CD19/CD22 CAR T-cells CT120 bind to CD19 and CD22 on the surface of, and induce selective toxicity against, tumor cells expressing CD19 and CD22. CD19 and CD22, both transmembrane phosphoglycoproteins expressed on the surface of cells in the B lineage, are overexpressed on malignant B-cells." @default.
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- NCIT_C142834 NCIT_P107 "Autologous CD19/CD22 Chimeric Antigen Receptor T-cells CT120" @default.
- NCIT_C142834 NCIT_P108 "Autologous CD19/CD22 Chimeric Antigen Receptor T-cells CT120" @default.
- NCIT_C142834 NCIT_P208 "CL540702" @default.
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- NCIT_C142834 NCIT_P330 "791791" @default.
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- NCIT_C142834 normalizedInformationContent "100" @default.
- NCIT_C142834 referenceCount "1" @default.
- NCIT_C142834 hasExactSynonym "Autologous Anti-CD19/CD22 CAR-T Cells" @default.
- NCIT_C142834 hasExactSynonym "Autologous CD19/CD22 CAR T Cells" @default.
- NCIT_C142834 hasExactSynonym "Autologous CD19/CD22 CAR T-cells" @default.
- NCIT_C142834 hasExactSynonym "Autologous CD19/CD22 Chimeric Antigen Receptor T Cells" @default.
- NCIT_C142834 hasExactSynonym "Autologous CD19/CD22 Chimeric Antigen Receptor T-cells CT120" @default.
- NCIT_C142834 hasExactSynonym "CD19/CD22 Bispecific CAR-T" @default.
- NCIT_C142834 hasExactSynonym "CD19/CD22 CAR-T" @default.
- NCIT_C142834 hasExactSynonym "CT 120" @default.
- NCIT_C142834 hasExactSynonym "CT-120" @default.
- NCIT_C142834 hasExactSynonym "CT120" @default.
- NCIT_C142834 inSubset NCIT_C116977 @default.
- NCIT_C142834 inSubset NCIT_C116978 @default.
- NCIT_C142834 inSubset NCIT_C128784 @default.
- NCIT_C142834 inSubset NCIT_C176424 @default.
- NCIT_C142834 type Class @default.
- NCIT_C142834 isDefinedBy ncit.owl @default.
- NCIT_C142834 label "Autologous CD19/CD22 Chimeric Antigen Receptor T-cells CT120" @default.
- NCIT_C142834 subClassOf NCIT_C129820 @default.
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- NCIT_C142834 subClassOf NCIT_C201173 @default.
- NCIT_C142834 subClassOf NCIT_C274 @default.
- NCIT_C142834 subClassOf NCIT_C28681 @default.
- NCIT_C142834 subClassOf NCIT_C307 @default.
- NCIT_C142834 subClassOf NCIT_C308 @default.