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- NCIT_C142890 IAO_0000115 "A bivalent, bispecific fusion protein comprised of an anti-human epidermal growth factor receptor (HER2) monoclonal antibody linked to a CD137-targeting anticalin with potential immunostimulatory and antineoplastic activities. Upon administration of cinrebafusp alfa, CD137 clustering is promoted by bridging CD137-positive T-cells with HER2-positive tumor cells, leading to the recruitment of tumor antigen-specific cytotoxic T-lymphocytes (CTLs). This may result in potent CTL-mediated lysis of HER2-expressing tumor cells. HER2 plays a key role in tumor cell proliferation and tumor vascularization. CD137 is a costimulatory immunoreceptor and a member of the tumor necrosis factor receptor superfamily (TNFRSF). Anticalins are synthetic antigen-binding proteins derived from lipocalins. Structurally dissimilar to antibodies, anticalins are able to bind to smaller antigens and exhibit improved tissue penetration." @default.
- NCIT_C142890 NCIT_A32 NCIT_C1909 @default.
- NCIT_C142890 NCIT_A7 NCIT_C105113 @default.
- NCIT_C142890 NCIT_A7 NCIT_C17319 @default.
- NCIT_C142890 NCIT_NHC0 "C142890" @default.
- NCIT_C142890 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C142890 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C142890 NCIT_P107 "Cinrebafusp Alfa" @default.
- NCIT_C142890 NCIT_P108 "Cinrebafusp Alfa" @default.
- NCIT_C142890 NCIT_P208 "CL541381" @default.
- NCIT_C142890 NCIT_P210 "2218515-90-1" @default.
- NCIT_C142890 NCIT_P319 "21Z359Z1CV" @default.
- NCIT_C142890 NCIT_P322 "CTRP" @default.
- NCIT_C142890 NCIT_P322 "FDA" @default.
- NCIT_C142890 NCIT_P322 "GDC" @default.
- NCIT_C142890 NCIT_P329 "791831" @default.
- NCIT_C142890 NCIT_P330 "791831" @default.
- NCIT_C142890 NCIT_P375 "Anti-HER2 Monoclonal Antibody/Anti-CD137 Anticalin Bispecific Fusion Protein PRS-343" @default.
- NCIT_C142890 NCIT_P375 "Cinrebafusp Alfa" @default.
- NCIT_C142890 NCIT_P399 "791831" @default.
- NCIT_C142890 normalizedInformationContent "100" @default.
- NCIT_C142890 referenceCount "1" @default.
- NCIT_C142890 hasExactSynonym "Anti-HER2 Monoclonal Antibody/Anti-CD137 Anticalin Bispecific Fusion Protein PRS-343" @default.
- NCIT_C142890 hasExactSynonym "CINREBAFUSP ALFA" @default.
- NCIT_C142890 hasExactSynonym "Cinrebafusp Alfa" @default.
- NCIT_C142890 hasExactSynonym "PRS-343" @default.
- NCIT_C142890 inSubset NCIT_C116977 @default.
- NCIT_C142890 inSubset NCIT_C116978 @default.
- NCIT_C142890 inSubset NCIT_C128784 @default.
- NCIT_C142890 inSubset NCIT_C157711 @default.
- NCIT_C142890 inSubset NCIT_C157712 @default.
- NCIT_C142890 inSubset NCIT_C176424 @default.
- NCIT_C142890 inSubset NCIT_C177537 @default.
- NCIT_C142890 inSubset NCIT_C63923 @default.
- NCIT_C142890 type Class @default.
- NCIT_C142890 isDefinedBy ncit.owl @default.
- NCIT_C142890 label "Cinrebafusp Alfa" @default.
- NCIT_C142890 subClassOf NCIT_C129820 @default.
- NCIT_C142890 subClassOf NCIT_C142890 @default.
- NCIT_C142890 subClassOf NCIT_C163758 @default.
- NCIT_C142890 subClassOf NCIT_C163760 @default.
- NCIT_C142890 subClassOf NCIT_C1908 @default.
- NCIT_C142890 subClassOf NCIT_C1909 @default.
- NCIT_C142890 subClassOf NCIT_C192997 @default.
- NCIT_C142890 subClassOf NCIT_C274 @default.
- NCIT_C142890 subClassOf NCIT_C308 @default.