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- NCIT_C142897 IAO_0000115 "The hydrochloride salt form of abexinostat, an orally bioavailable hydroxamate-based pan-inhibitor of histone deacetylase (HDAC), with potential antineoplastic and radiosensitizing activities. Upon administration, abexinostat inhibits HDAC, resulting in an accumulation of highly acetylated histones, followed by the induction of chromatin remodeling; the selective transcription of tumor suppressor genes; and the tumor suppressor protein-mediated inhibition of tumor cell division and induction of tumor cell apoptosis. In addition, abexinostat decreases the expression of the DNA-repair protein RAD51, thereby reducing the RAD51 protein, preventing repair of DNA double-strand breaks and increasing sensitivity of tumor cells to DNA damaging agents. HDAC, upregulated in many tumor types, is an enzyme that is responsible for the deacetylation of chromatin histone proteins." @default.
- NCIT_C142897 NCIT_NHC0 "C142897" @default.
- NCIT_C142897 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C142897 NCIT_P108 "Abexinostat Hydrochloride" @default.
- NCIT_C142897 NCIT_P208 "CL541373" @default.
- NCIT_C142897 NCIT_P210 "783356-67-2" @default.
- NCIT_C142897 NCIT_P319 "T1E6TM0SVG" @default.
- NCIT_C142897 NCIT_P322 "FDA" @default.
- NCIT_C142897 normalizedInformationContent "100" @default.
- NCIT_C142897 referenceCount "1" @default.
- NCIT_C142897 hasExactSynonym "ABEXINOSTAT HYDROCHLORIDE" @default.
- NCIT_C142897 hasExactSynonym "Abexinostat Hydrochloride" @default.
- NCIT_C142897 inSubset NCIT_C63923 @default.
- NCIT_C142897 type Class @default.
- NCIT_C142897 isDefinedBy ncit.owl @default.
- NCIT_C142897 label "Abexinostat Hydrochloride" @default.
- NCIT_C142897 subClassOf NCIT_C142897 @default.
- NCIT_C142897 subClassOf NCIT_C163758 @default.
- NCIT_C142897 subClassOf NCIT_C1908 @default.
- NCIT_C142897 subClassOf NCIT_C1909 @default.
- NCIT_C142897 subClassOf NCIT_C1946 @default.
- NCIT_C142897 subClassOf NCIT_C274 @default.
- NCIT_C142897 subClassOf NCIT_C471 @default.