Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C142912> ?p ?o ?g. }
Showing items 1 to 46 of
46
with 100 items per page.
- NCIT_C142912 IAO_0000115 "The sodium salt form of alisertib, a second-generation, orally bioavailable, selective inhibitor of the serine/threonine protein kinase Aurora A kinase, with potential antineoplastic activity. Upon oral administration, alisertib targets, binds to and inhibits Aurora A kinase, which may result in disruption of the assembly of the mitotic spindle apparatus, disruption of chromosome segregation, and inhibition of cell proliferation in susceptible cancer cells. Aurora A kinase localizes to the spindle poles and to spindle microtubules during mitosis, and is thought to regulate spindle assembly. Aberrant expression of Aurora kinases occurs in a wide variety of cancers and plays a key role in cancer cell proliferation." @default.
- NCIT_C142912 NCIT_A6 NCIT_C71717 @default.
- NCIT_C142912 NCIT_A7 NCIT_C30006 @default.
- NCIT_C142912 NCIT_NHC0 "C142912" @default.
- NCIT_C142912 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C142912 NCIT_P107 "Alisertib Sodium" @default.
- NCIT_C142912 NCIT_P108 "Alisertib Sodium" @default.
- NCIT_C142912 NCIT_P208 "CL541357" @default.
- NCIT_C142912 NCIT_P210 "1208255-63-3" @default.
- NCIT_C142912 NCIT_P319 "T76P158V9D" @default.
- NCIT_C142912 NCIT_P322 "CTRP" @default.
- NCIT_C142912 NCIT_P322 "FDA" @default.
- NCIT_C142912 NCIT_P399 "810689" @default.
- NCIT_C142912 NCIT_R146 NCIT_C16554 @default.
- NCIT_C142912 NCIT_R146 NCIT_C16984 @default.
- NCIT_C142912 NCIT_R146 NCIT_C17018 @default.
- NCIT_C142912 NCIT_R146 NCIT_C17021 @default.
- NCIT_C142912 NCIT_R146 NCIT_C17210 @default.
- NCIT_C142912 NCIT_R146 NCIT_C17325 @default.
- NCIT_C142912 NCIT_R146 NCIT_C20027 @default.
- NCIT_C142912 NCIT_R146 NCIT_C26548 @default.
- NCIT_C142912 NCIT_R146 NCIT_C30006 @default.
- NCIT_C142912 normalizedInformationContent "100" @default.
- NCIT_C142912 referenceCount "1" @default.
- NCIT_C142912 hasExactSynonym "ALISERTIB SODIUM" @default.
- NCIT_C142912 hasExactSynonym "Alisertib Sodium" @default.
- NCIT_C142912 hasExactSynonym "MLN8237 Sodium" @default.
- NCIT_C142912 hasExactSynonym "MLN8237-004" @default.
- NCIT_C142912 inSubset NCIT_C116977 @default.
- NCIT_C142912 inSubset NCIT_C116978 @default.
- NCIT_C142912 inSubset NCIT_C176424 @default.
- NCIT_C142912 inSubset NCIT_C63923 @default.
- NCIT_C142912 type Class @default.
- NCIT_C142912 isDefinedBy ncit.owl @default.
- NCIT_C142912 label "Alisertib Sodium" @default.
- NCIT_C142912 subClassOf NCIT_C129824 @default.
- NCIT_C142912 subClassOf NCIT_C129825 @default.
- NCIT_C142912 subClassOf NCIT_C1404 @default.
- NCIT_C142912 subClassOf NCIT_C142912 @default.
- NCIT_C142912 subClassOf NCIT_C1908 @default.
- NCIT_C142912 subClassOf NCIT_C1909 @default.
- NCIT_C142912 subClassOf NCIT_C2189 @default.
- NCIT_C142912 subClassOf NCIT_C274 @default.
- NCIT_C142912 subClassOf NCIT_C471 @default.
- NCIT_C142912 subClassOf NCIT_C61074 @default.
- NCIT_C142912 subClassOf NCIT_C62556 @default.