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- NCIT_C142924 IAO_0000115 "The acetate salt form of therapeutic angiotensin II, a synthetic form of the endogenous angiotensin II, a peptide hormone of the renin-angiotensin-aldosterone system (RAAS) that causes vasoconstriction and an increase in blood pressure, that may be used for the treatment of septic or other distributive shock. Upon administration, therapeutic angiotensin II binds to angiotensin II type 1 receptor on vascular smooth muscle cells which leads to Ca2+/calmodulin-dependent phosphorylation of myosin. This causes smooth muscle contraction and results in vasoconstriction and an increase in blood pressure. Therapeutic angiotensin II also increases blood pressure by stimulating the release of the steroid hormone aldosterone, which regulates the renal absorption of water and sodium." @default.
- NCIT_C142924 NCIT_NHC0 "C142924" @default.
- NCIT_C142924 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C142924 NCIT_P108 "Angiotensin II Acetate" @default.
- NCIT_C142924 NCIT_P208 "CL541352" @default.
- NCIT_C142924 NCIT_P210 "68521-88-0" @default.
- NCIT_C142924 NCIT_P319 "31L3HS630A" @default.
- NCIT_C142924 NCIT_P322 "FDA" @default.
- NCIT_C142924 normalizedInformationContent "100" @default.
- NCIT_C142924 referenceCount "1" @default.
- NCIT_C142924 hasExactSynonym "ANGIOTENSIN II ACETATE" @default.
- NCIT_C142924 hasExactSynonym "Angiotensin II Acetate" @default.
- NCIT_C142924 hasExactSynonym "Giapreza" @default.
- NCIT_C142924 inSubset NCIT_C173381 @default.
- NCIT_C142924 inSubset NCIT_C173383 @default.
- NCIT_C142924 inSubset NCIT_C63923 @default.
- NCIT_C142924 type Class @default.
- NCIT_C142924 isDefinedBy ncit.owl @default.
- NCIT_C142924 label "Angiotensin II Acetate" @default.
- NCIT_C142924 subClassOf NCIT_C142924 @default.
- NCIT_C142924 subClassOf NCIT_C1908 @default.
- NCIT_C142924 subClassOf NCIT_C1909 @default.
- NCIT_C142924 subClassOf NCIT_C307 @default.