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- NCIT_C142941 IAO_0000115 "The maleate salt form of avatrombopag, an orally available platelet thrombopoietin receptor (TPOR; MPL) agonist, with potential megakaryopoiesis stimulating activity. Upon administration, avatrombopag binds to and stimulates TPOR, which may lead to the proliferation and differentiation of megakaryocytes from bone marrow progenitor cells. This increases the production of platelets and may prevent chemotherapy-induced thrombocytopenia (CIT). TPOR is a cytokine receptor and member of the hematopoietin receptor superfamily." @default.
- NCIT_C142941 NCIT_NHC0 "C142941" @default.
- NCIT_C142941 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C142941 NCIT_P108 "Avatrombopag Maleate" @default.
- NCIT_C142941 NCIT_P208 "CL541337" @default.
- NCIT_C142941 NCIT_P210 "677007-74-8" @default.
- NCIT_C142941 NCIT_P319 "GDW7M2P1IS" @default.
- NCIT_C142941 NCIT_P322 "FDA" @default.
- NCIT_C142941 NCIT_P329 "793425" @default.
- NCIT_C142941 NCIT_P330 "793425" @default.
- NCIT_C142941 NCIT_P399 "793425" @default.
- NCIT_C142941 normalizedInformationContent "100" @default.
- NCIT_C142941 referenceCount "1" @default.
- NCIT_C142941 hasExactSynonym "1-(3-Chloro-5-((4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2- yl)carbamoyl)pyridin-2-yl)piperidine-4-carboxylic acid mono-(2Z)-but-2-enedioate" @default.
- NCIT_C142941 hasExactSynonym "4-Piperidinecarboxylic Acid, 1-(3-Chloro-5-(((4-(4-chloro-2-thienyl)-5-(4-cyclohexyl-1- piperazinyl)-2-thiazolyl)amino)carbonyl)-2-pyridinyl)-, (2Z)-2-butenedioate (1:1)" @default.
- NCIT_C142941 hasExactSynonym "AVATROMBOPAG MALEATE" @default.
- NCIT_C142941 hasExactSynonym "Avatrombopag Maleate" @default.
- NCIT_C142941 hasExactSynonym "E5501 Maleate" @default.
- NCIT_C142941 inSubset NCIT_C176424 @default.
- NCIT_C142941 inSubset NCIT_C63923 @default.
- NCIT_C142941 type Class @default.
- NCIT_C142941 isDefinedBy ncit.owl @default.
- NCIT_C142941 label "Avatrombopag Maleate" @default.
- NCIT_C142941 subClassOf NCIT_C142941 @default.
- NCIT_C142941 subClassOf NCIT_C1908 @default.
- NCIT_C142941 subClassOf NCIT_C1909 @default.
- NCIT_C142941 subClassOf NCIT_C78275 @default.