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- NCIT_C142949 IAO_0000115 "The fumarate salt form of bedaquiline, an orally bioavailable diarylquinoline antimycobacterial agent, that can be used in the treatment of pulmonary multi-drug resistant tuberculosis (MDR-TB). Upon oral administration, bedaquiline specifically binds to subunit c of Mycobacterium tuberculosis (M. tuberculosis) adenosine 5'-triphosphate (ATP) synthase, thereby preventing ATP synthase activity. This inhibits ATP synthesis in M. tuberculosis, thereby blocking its energy metabolism and killing M. tuberculosis." @default.
- NCIT_C142949 NCIT_NHC0 "C142949" @default.
- NCIT_C142949 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C142949 NCIT_P108 "Bedaquiline Fumarate" @default.
- NCIT_C142949 NCIT_P207 "C3530515" @default.
- NCIT_C142949 NCIT_P210 "845533-86-0" @default.
- NCIT_C142949 NCIT_P319 "P04QX2C1A5" @default.
- NCIT_C142949 NCIT_P322 "FDA" @default.
- NCIT_C142949 normalizedInformationContent "100" @default.
- NCIT_C142949 referenceCount "1" @default.
- NCIT_C142949 hasExactSynonym "BDQ Fumarate" @default.
- NCIT_C142949 hasExactSynonym "BEDAQUILINE FUMARATE" @default.
- NCIT_C142949 hasExactSynonym "Bedaquiline Fumarate" @default.
- NCIT_C142949 hasExactSynonym "R403323" @default.
- NCIT_C142949 hasExactSynonym "Sirturo" @default.
- NCIT_C142949 inSubset NCIT_C63923 @default.
- NCIT_C142949 type Class @default.
- NCIT_C142949 isDefinedBy ncit.owl @default.
- NCIT_C142949 label "Bedaquiline Fumarate" @default.
- NCIT_C142949 subClassOf NCIT_C142949 @default.
- NCIT_C142949 subClassOf NCIT_C1908 @default.
- NCIT_C142949 subClassOf NCIT_C1909 @default.
- NCIT_C142949 subClassOf NCIT_C254 @default.
- NCIT_C142949 subClassOf NCIT_C280 @default.
- NCIT_C142949 subClassOf NCIT_C52588 @default.