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- NCIT_C142978 IAO_0000115 "A humanized, immunoglobulin G4 (IgG4) monoclonal antibody directed against the inhibitory receptor lymphocyte activation gene 3 protein (LAG3; LAG-3), with potential immune checkpoint inhibitory and antineoplastic activities. Upon administration,encelimab binds to LAG3 expressed on tumor-infiltrating lymphocytes (TILs) and blocks its binding with major histocompatibility complex (MHC) class II molecules expressed on tumor cells. This activates antigen-specific T-lymphocytes and enhances cytotoxic T-cell-mediated tumor cell lysis, which leads to a reduction in tumor growth. LAG3, a member of the immunoglobulin superfamily (IgSF), is expressed on various immune cells, and negatively regulates both proliferation and activation of T-cells. Its expression on TILs is associated with tumor-mediated immune suppression." @default.
- NCIT_C142978 NCIT_A32 NCIT_C1909 @default.
- NCIT_C142978 NCIT_A7 NCIT_C104623 @default.
- NCIT_C142978 NCIT_NHC0 "C142978" @default.
- NCIT_C142978 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C142978 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C142978 NCIT_P107 "Encelimab" @default.
- NCIT_C142978 NCIT_P108 "Encelimab" @default.
- NCIT_C142978 NCIT_P208 "CL541410" @default.
- NCIT_C142978 NCIT_P210 "2173096-82-5" @default.
- NCIT_C142978 NCIT_P319 "N151VZIIPD" @default.
- NCIT_C142978 NCIT_P322 "CTRP" @default.
- NCIT_C142978 NCIT_P322 "FDA" @default.
- NCIT_C142978 NCIT_P322 "GDC" @default.
- NCIT_C142978 NCIT_P329 "791832" @default.
- NCIT_C142978 NCIT_P330 "791832" @default.
- NCIT_C142978 NCIT_P375 "Anti-LAG3 Monoclonal Antibody TSR-033" @default.
- NCIT_C142978 NCIT_P375 "Encelimab" @default.
- NCIT_C142978 NCIT_P399 "791832" @default.
- NCIT_C142978 NCIT_R124 NCIT_C17710 @default.
- NCIT_C142978 NCIT_R124 NCIT_C17828 @default.
- NCIT_C142978 NCIT_R124 NCIT_C18219 @default.
- NCIT_C142978 NCIT_R124 NCIT_C19986 @default.
- NCIT_C142978 NCIT_R124 NCIT_C40474 @default.
- NCIT_C142978 normalizedInformationContent "100" @default.
- NCIT_C142978 referenceCount "1" @default.
- NCIT_C142978 hasExactSynonym "Anti-LAG-3 Monoclonal Antibody TSR-033" @default.
- NCIT_C142978 hasExactSynonym "Anti-LAG3 Monoclonal Antibody TSR-033" @default.
- NCIT_C142978 hasExactSynonym "Anti-Lymphocyte Activation Gene 3 Protein Monoclonal Antibody TSR-033" @default.
- NCIT_C142978 hasExactSynonym "ENCELIMAB" @default.
- NCIT_C142978 hasExactSynonym "Encelimab" @default.
- NCIT_C142978 hasExactSynonym "TSR 033" @default.
- NCIT_C142978 hasExactSynonym "TSR-033" @default.
- NCIT_C142978 hasExactSynonym "TSR033" @default.
- NCIT_C142978 inSubset NCIT_C116977 @default.
- NCIT_C142978 inSubset NCIT_C116978 @default.
- NCIT_C142978 inSubset NCIT_C128784 @default.
- NCIT_C142978 inSubset NCIT_C157711 @default.
- NCIT_C142978 inSubset NCIT_C157712 @default.
- NCIT_C142978 inSubset NCIT_C176424 @default.
- NCIT_C142978 inSubset NCIT_C177537 @default.
- NCIT_C142978 inSubset NCIT_C63923 @default.
- NCIT_C142978 type Class @default.
- NCIT_C142978 isDefinedBy ncit.owl @default.
- NCIT_C142978 label "Encelimab" @default.
- NCIT_C142978 subClassOf NCIT_C129821 @default.
- NCIT_C142978 subClassOf NCIT_C129822 @default.
- NCIT_C142978 subClassOf NCIT_C134305 @default.
- NCIT_C142978 subClassOf NCIT_C141144 @default.
- NCIT_C142978 subClassOf NCIT_C142978 @default.
- NCIT_C142978 subClassOf NCIT_C143250 @default.
- NCIT_C142978 subClassOf NCIT_C163758 @default.
- NCIT_C142978 subClassOf NCIT_C1908 @default.
- NCIT_C142978 subClassOf NCIT_C1909 @default.
- NCIT_C142978 subClassOf NCIT_C200483 @default.
- NCIT_C142978 subClassOf NCIT_C20401 @default.
- NCIT_C142978 subClassOf NCIT_C274 @default.
- NCIT_C142978 subClassOf NCIT_C307 @default.
- NCIT_C142978 subClassOf NCIT_C308 @default.