Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C143035> ?p ?o ?g. }
Showing items 1 to 43 of
43
with 100 items per page.
- NCIT_C143035 IAO_0000115 "A therapeutic cancer vaccine composed of a replication-defective, serotype 5 adenovirus (Ad5) with the viral genes early 1 (E1), early 2b (E2b), and early 3 (E3) deleted, and the human glycoprotein mucin 1 (MUC1) encoded, with potential immunostimulating and antineoplastic activities. Upon subcutaneous administration, the adenoviral MUC1 vaccine ETBX-061 expresses the MUC1 protein. The expressed MUC1 may induce a cytotoxic T-lymphocyte (CTL)-mediated immune response against tumor cells expressing MUC1, thereby resulting in both immune-mediated inhibition of tumor cell proliferation and tumor cell death. Deletion of the E1, E2b and E3 genes from Ad5 prevents anti-adenovirus immune responses. MUC1, a tumor-associated antigen (TAA) and type I transmembrane protein, is overexpressed in a variety of tumor types. It plays an important role in cancer progression and metastasis." @default.
- NCIT_C143035 NCIT_A32 NCIT_C1909 @default.
- NCIT_C143035 NCIT_A7 NCIT_C38967 @default.
- NCIT_C143035 NCIT_NHC0 "C143035" @default.
- NCIT_C143035 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C143035 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C143035 NCIT_P107 "Adenoviral MUC1 Vaccine ETBX-061" @default.
- NCIT_C143035 NCIT_P108 "Adenoviral MUC1 Vaccine ETBX-061" @default.
- NCIT_C143035 NCIT_P208 "CL541479" @default.
- NCIT_C143035 NCIT_P210 "2171550-29-9" @default.
- NCIT_C143035 NCIT_P319 "17K7SN702N" @default.
- NCIT_C143035 NCIT_P322 "CTRP" @default.
- NCIT_C143035 NCIT_P322 "FDA" @default.
- NCIT_C143035 NCIT_P322 "GDC" @default.
- NCIT_C143035 NCIT_P329 "791864" @default.
- NCIT_C143035 NCIT_P330 "791864" @default.
- NCIT_C143035 NCIT_P375 "Adenoviral MUC1 Vaccine ETBX-061" @default.
- NCIT_C143035 NCIT_P399 "791864" @default.
- NCIT_C143035 normalizedInformationContent "100" @default.
- NCIT_C143035 referenceCount "1" @default.
- NCIT_C143035 hasExactSynonym "Ad5-MUC1 vaccine" @default.
- NCIT_C143035 hasExactSynonym "Adenoviral MUC1 Vaccine ETBX-061" @default.
- NCIT_C143035 hasExactSynonym "ETBX 061" @default.
- NCIT_C143035 hasExactSynonym "ETBX-061" @default.
- NCIT_C143035 inSubset NCIT_C116977 @default.
- NCIT_C143035 inSubset NCIT_C116978 @default.
- NCIT_C143035 inSubset NCIT_C128784 @default.
- NCIT_C143035 inSubset NCIT_C157711 @default.
- NCIT_C143035 inSubset NCIT_C157712 @default.
- NCIT_C143035 inSubset NCIT_C176424 @default.
- NCIT_C143035 inSubset NCIT_C177537 @default.
- NCIT_C143035 inSubset NCIT_C63923 @default.
- NCIT_C143035 type Class @default.
- NCIT_C143035 isDefinedBy ncit.owl @default.
- NCIT_C143035 label "Adenoviral MUC1 Vaccine ETBX-061" @default.
- NCIT_C143035 subClassOf NCIT_C143035 @default.
- NCIT_C143035 subClassOf NCIT_C1572 @default.
- NCIT_C143035 subClassOf NCIT_C1908 @default.
- NCIT_C143035 subClassOf NCIT_C1909 @default.
- NCIT_C143035 subClassOf NCIT_C307 @default.
- NCIT_C143035 subClassOf NCIT_C308 @default.
- NCIT_C143035 subClassOf NCIT_C923 @default.
- NCIT_C143035 subClassOf NCIT_C96404 @default.