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- NCIT_C143068 IAO_0000115 "An orally available inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1; IDO-1), with potential immunomodulating and antineoplastic activities. Upon administration, IDO1 inhibitor LY3381916 specifically targets and binds to IDO1, a cytosolic enzyme responsible for the oxidation of the amino acid tryptophan into the immunosuppressive metabolite kynurenine. By inhibiting IDO1 and decreasing kynurenine in tumor cells, LY3381916 restores and promotes the proliferation and activation of various immune cells, including dendritic cells (DCs), natural killer (NK) cells, and T-lymphocytes, and causes a reduction in tumor-associated regulatory T-cells (Tregs). Activation of the immune system, which is suppressed in many cancers, may induce a cytotoxic T-lymphocyte (CTL) response against the IDO1-expressing tumor cells, thereby inhibiting the growth of IDO1-expressing tumor cells. IDO1, overexpressed by multiple tumor cell types, plays an important role in immunosuppression. Tryptophan depletion inhibits T-lymphocyte proliferation and activation, and subsequently suppresses the immune system." @default.
- NCIT_C143068 NCIT_A32 NCIT_C1909 @default.
- NCIT_C143068 NCIT_A7 NCIT_C79782 @default.
- NCIT_C143068 NCIT_NHC0 "C143068" @default.
- NCIT_C143068 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C143068 NCIT_P107 "IDO-1 Inhibitor LY3381916" @default.
- NCIT_C143068 NCIT_P108 "IDO-1 Inhibitor LY3381916" @default.
- NCIT_C143068 NCIT_P208 "CL541448" @default.
- NCIT_C143068 NCIT_P322 "CTRP" @default.
- NCIT_C143068 NCIT_P322 "GDC" @default.
- NCIT_C143068 NCIT_P329 "794987" @default.
- NCIT_C143068 NCIT_P330 "794987" @default.
- NCIT_C143068 NCIT_P375 "IDO-1 Inhibitor LY3381916" @default.
- NCIT_C143068 NCIT_P399 "794987" @default.
- NCIT_C143068 normalizedInformationContent "100" @default.
- NCIT_C143068 referenceCount "1" @default.
- NCIT_C143068 hasExactSynonym "IDO-1 Inhibitor LY3381916" @default.
- NCIT_C143068 hasExactSynonym "IDO1 Inhibitor LY3381916" @default.
- NCIT_C143068 hasExactSynonym "LY-3381916" @default.
- NCIT_C143068 hasExactSynonym "LY3381916" @default.
- NCIT_C143068 inSubset NCIT_C116977 @default.
- NCIT_C143068 inSubset NCIT_C116978 @default.
- NCIT_C143068 inSubset NCIT_C128784 @default.
- NCIT_C143068 inSubset NCIT_C157711 @default.
- NCIT_C143068 inSubset NCIT_C157712 @default.
- NCIT_C143068 inSubset NCIT_C176424 @default.
- NCIT_C143068 inSubset NCIT_C177537 @default.
- NCIT_C143068 type Class @default.
- NCIT_C143068 isDefinedBy ncit.owl @default.
- NCIT_C143068 label "IDO-1 Inhibitor LY3381916" @default.
- NCIT_C143068 subClassOf NCIT_C129820 @default.
- NCIT_C143068 subClassOf NCIT_C141137 @default.
- NCIT_C143068 subClassOf NCIT_C141144 @default.
- NCIT_C143068 subClassOf NCIT_C143068 @default.
- NCIT_C143068 subClassOf NCIT_C1908 @default.
- NCIT_C143068 subClassOf NCIT_C1909 @default.
- NCIT_C143068 subClassOf NCIT_C274 @default.
- NCIT_C143068 subClassOf NCIT_C308 @default.
- NCIT_C143068 subClassOf NCIT_C471 @default.