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- NCIT_C143156 IAO_0000115 "Autologous T-lymphocytes that have been transduced with a lentiviral vector to express a chimeric antigen receptor (CAR) consisting of a single chain variable fragment (scFv) of anti-CD19 in tandem with an anti-CD20 scFv, and coupled to the cytoplasmic portion of the zeta chain of the human T-cell receptor (CD3zeta), and the co-stimulatory molecule 4-1BB (CD137), with potential immunostimulating and antineoplastic activities. Upon transfusion, anti-CD19-CD20-CAR-CD3zeta-4-1BB-expressing autologous T-lymphocytes recognize and direct T-cells to CD19- or CD20-expressing tumor B-cells. This results in a cytotoxic T-lymphocyte (CTL) response against CD19- or CD20-expressing tumor cells, and causes tumor cell lysis. Both CD19 and CD20 are B-cell-specific cell surface antigens overexpressed in B-cell lineage malignancies." @default.
- NCIT_C143156 NCIT_NHC0 "C143156" @default.
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- NCIT_C143156 NCIT_P108 "Anti-CD19-CD20-CAR-CD3zeta-4-1BB-expressing Autologous T-lymphocytes" @default.
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- NCIT_C143156 hasExactSynonym "Anti-CD19-CD20-CAR-CD3zeta-4-1BB-expressing Autologous T-lymphocytes" @default.
- NCIT_C143156 hasExactSynonym "Anti-CD19/CD20 CAR Autologous T-lymphocytes" @default.
- NCIT_C143156 hasExactSynonym "Autologous CAR-20/19-T Cells" @default.
- NCIT_C143156 inSubset NCIT_C128784 @default.
- NCIT_C143156 inSubset NCIT_C176424 @default.
- NCIT_C143156 type Class @default.
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- NCIT_C143156 label "Anti-CD19-CD20-CAR-CD3zeta-4-1BB-expressing Autologous T-lymphocytes" @default.
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