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- NCIT_C143158 IAO_0000115 "An aroylindole derivative and tubulin polymerization inhibitor, with potential tubulin-inhibiting, vascular-disrupting and antineoplastic activities. Upon administration, tubulin polymerization inhibitor SCB01A binds at the colchicine binding site of tubulin and prevents its polymerization in tumor blood vessel endothelial cells and in tumor cells. This blocks the formation of the mitotic spindle and leads to both cell cycle arrest at the G2/M phase and tumor cell apoptosis. Also, this agent's effect on the tumor blood vessel endothelial cells leads to a disruption of the tumor vasculature and tumor blood flow, which deprives tumor cells of nutrients and induces tumor cell apoptosis." @default.
- NCIT_C143158 NCIT_A32 NCIT_C1909 @default.
- NCIT_C143158 NCIT_NHC0 "C143158" @default.
- NCIT_C143158 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C143158 NCIT_P108 "Microtubule Inhibitor SCB01A" @default.
- NCIT_C143158 NCIT_P208 "CL541607" @default.
- NCIT_C143158 NCIT_P322 "GDC" @default.
- NCIT_C143158 NCIT_P329 "791849" @default.
- NCIT_C143158 NCIT_P330 "791849" @default.
- NCIT_C143158 NCIT_P375 "Microtubule Inhibitor SCB01A" @default.
- NCIT_C143158 NCIT_P399 "791849" @default.
- NCIT_C143158 NCIT_R124 NCIT_C17828 @default.
- NCIT_C143158 NCIT_R124 NCIT_C20480 @default.
- NCIT_C143158 NCIT_R124 NCIT_C40795 @default.
- NCIT_C143158 NCIT_R124 NCIT_C40798 @default.
- NCIT_C143158 normalizedInformationContent "100" @default.
- NCIT_C143158 referenceCount "1" @default.
- NCIT_C143158 hasExactSynonym "6-Methoxy-3-(3',4',5'-trimethoxybenzoyl) Indole" @default.
- NCIT_C143158 hasExactSynonym "BPR 0L075" @default.
- NCIT_C143158 hasExactSynonym "DBPR104" @default.
- NCIT_C143158 hasExactSynonym "Microtubule Inhibitor SCB01A" @default.
- NCIT_C143158 hasExactSynonym "SB 01" @default.
- NCIT_C143158 hasExactSynonym "SCB 01A" @default.
- NCIT_C143158 hasExactSynonym "SCB-01A" @default.
- NCIT_C143158 hasExactSynonym "SCB01A" @default.
- NCIT_C143158 inSubset NCIT_C128784 @default.
- NCIT_C143158 inSubset NCIT_C157711 @default.
- NCIT_C143158 inSubset NCIT_C157712 @default.
- NCIT_C143158 inSubset NCIT_C176424 @default.
- NCIT_C143158 inSubset NCIT_C177537 @default.
- NCIT_C143158 type Class @default.
- NCIT_C143158 isDefinedBy ncit.owl @default.
- NCIT_C143158 label "Microtubule Inhibitor SCB01A" @default.
- NCIT_C143158 subClassOf NCIT_C143158 @default.
- NCIT_C143158 subClassOf NCIT_C186664 @default.
- NCIT_C143158 subClassOf NCIT_C1908 @default.
- NCIT_C143158 subClassOf NCIT_C1909 @default.
- NCIT_C143158 subClassOf NCIT_C25974 @default.
- NCIT_C143158 subClassOf NCIT_C273 @default.
- NCIT_C143158 subClassOf NCIT_C274 @default.