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- NCIT_C143162 IAO_0000115 "An orally bioavailable, adenosine triphosphate (ATP) competitive inhibitor of polo-like kinase 1 (PLK1; PLK-1; STPK13), with potential antineoplastic activity. Upon administration, onvansertib selectively binds to and inhibits PLK1, which disrupts mitosis and induces selective G2/M cell-cycle arrest followed by apoptosis in PLK1-overexpressing tumor cells. PLK1, named after the polo gene of Drosophila melanogaster, is a serine/threonine kinase that is crucial for the regulation of mitosis, and plays a key role in tumor cell proliferation. PLK1 expression is upregulated in a variety of tumor cell types and high expression is associated with increased aggressiveness and poor prognosis." @default.
- NCIT_C143162 NCIT_A32 NCIT_C1909 @default.
- NCIT_C143162 NCIT_A7 NCIT_C17911 @default.
- NCIT_C143162 NCIT_NHC0 "C143162" @default.
- NCIT_C143162 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C143162 NCIT_P107 "Onvansertib" @default.
- NCIT_C143162 NCIT_P108 "Onvansertib" @default.
- NCIT_C143162 NCIT_P208 "CL541611" @default.
- NCIT_C143162 NCIT_P210 "1034616-18-6" @default.
- NCIT_C143162 NCIT_P319 "67RM91WDHQ" @default.
- NCIT_C143162 NCIT_P322 "CTRP" @default.
- NCIT_C143162 NCIT_P322 "FDA" @default.
- NCIT_C143162 NCIT_P322 "GDC" @default.
- NCIT_C143162 NCIT_P329 "792149" @default.
- NCIT_C143162 NCIT_P330 "792149" @default.
- NCIT_C143162 NCIT_P375 "Onvansertib" @default.
- NCIT_C143162 NCIT_P375 "Polo-like Kinase 1 Inhibitor NMS-1286937" @default.
- NCIT_C143162 NCIT_P399 "792149" @default.
- NCIT_C143162 normalizedInformationContent "100" @default.
- NCIT_C143162 referenceCount "1" @default.
- NCIT_C143162 hasExactSynonym "'PLK1 Inhibitor PCM-075" @default.
- NCIT_C143162 hasExactSynonym "NMS-1286937" @default.
- NCIT_C143162 hasExactSynonym "ONVANSERTIB" @default.
- NCIT_C143162 hasExactSynonym "Onvansertib" @default.
- NCIT_C143162 hasExactSynonym "PCM 075" @default.
- NCIT_C143162 hasExactSynonym "PCM-075" @default.
- NCIT_C143162 hasExactSynonym "PLK-1 Inhibitor PCM-075" @default.
- NCIT_C143162 hasExactSynonym "Polo-like Kinase 1 Inhibitor NMS-1286937" @default.
- NCIT_C143162 hasExactSynonym "Polo-like Kinase 1 Inhibitor PCM-075" @default.
- NCIT_C143162 inSubset NCIT_C116977 @default.
- NCIT_C143162 inSubset NCIT_C116978 @default.
- NCIT_C143162 inSubset NCIT_C128784 @default.
- NCIT_C143162 inSubset NCIT_C157711 @default.
- NCIT_C143162 inSubset NCIT_C157712 @default.
- NCIT_C143162 inSubset NCIT_C176424 @default.
- NCIT_C143162 inSubset NCIT_C177537 @default.
- NCIT_C143162 inSubset NCIT_C63923 @default.
- NCIT_C143162 type Class @default.
- NCIT_C143162 isDefinedBy ncit.owl @default.
- NCIT_C143162 label "Onvansertib" @default.
- NCIT_C143162 subClassOf NCIT_C129824 @default.
- NCIT_C143162 subClassOf NCIT_C129825 @default.
- NCIT_C143162 subClassOf NCIT_C1404 @default.
- NCIT_C143162 subClassOf NCIT_C143162 @default.
- NCIT_C143162 subClassOf NCIT_C177899 @default.
- NCIT_C143162 subClassOf NCIT_C1908 @default.
- NCIT_C143162 subClassOf NCIT_C1909 @default.
- NCIT_C143162 subClassOf NCIT_C2189 @default.
- NCIT_C143162 subClassOf NCIT_C274 @default.
- NCIT_C143162 subClassOf NCIT_C471 @default.
- NCIT_C143162 subClassOf NCIT_C61074 @default.