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- NCIT_C143956 IAO_0000115 "A cancer vaccine composed of enveloped virus-like particles (eVLPs) containing the human cytomegalovirus (CMV) antigens glycoprotein B (gB) and phosphoprotein 65 (pp65; UL83) that are combined with the immunoadjuvant granulocyte-macrophage colony-stimulating factor (GM-CSF), with potential immunostimulatory and antineoplastic activities. Upon intradermal administration of VBI-1901, the eVLPs are taken up by and activate immune cells, such as dendritic cells (DCs), thereby stimulating the immune system to exert a cytotoxic T-lymphocyte (CTL) immune response against CMV gB and pp65-expressing tumor cells. This may lyse and inhibit the proliferation of CMV-infected cancer cells. eVLPs, derived from viral structural proteins, stimulate the immune system and promote CTL responses. CMV gB and pp65 are expressed in certain tumor cell types, such as glioblastoma multiforme (GBM). GM-CSF stimulates the immune system and potentiates the antitumor immune response." @default.
- NCIT_C143956 NCIT_A7 NCIT_C132331 @default.
- NCIT_C143956 NCIT_A7 NCIT_C141213 @default.
- NCIT_C143956 NCIT_NHC0 "C143956" @default.
- NCIT_C143956 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C143956 NCIT_P107 "eVLP CMV gB-pp65 Plus GM-CSF VBI-1901" @default.
- NCIT_C143956 NCIT_P108 "eVLP CMV gB-pp65 Plus GM-CSF VBI-1901" @default.
- NCIT_C143956 NCIT_P208 "CL542158" @default.
- NCIT_C143956 NCIT_P322 "CTRP" @default.
- NCIT_C143956 NCIT_P329 "792152" @default.
- NCIT_C143956 NCIT_P330 "792152" @default.
- NCIT_C143956 NCIT_P399 "792152" @default.
- NCIT_C143956 normalizedInformationContent "100" @default.
- NCIT_C143956 referenceCount "1" @default.
- NCIT_C143956 hasExactSynonym "Enveloped Virus-like Particles CMV gB-pp65 Plus GM-CSF VBI-1901" @default.
- NCIT_C143956 hasExactSynonym "VBI 1901" @default.
- NCIT_C143956 hasExactSynonym "VBI-1901 Vaccine" @default.
- NCIT_C143956 hasExactSynonym "VBI-1901" @default.
- NCIT_C143956 hasExactSynonym "eVLP CMV gB-pp65 Plus GM-CSF VBI-1901" @default.
- NCIT_C143956 inSubset NCIT_C116977 @default.
- NCIT_C143956 inSubset NCIT_C116978 @default.
- NCIT_C143956 inSubset NCIT_C176424 @default.
- NCIT_C143956 type Class @default.
- NCIT_C143956 isDefinedBy ncit.owl @default.
- NCIT_C143956 label "eVLP CMV gB-pp65 Plus GM-CSF VBI-1901" @default.
- NCIT_C143956 subClassOf NCIT_C129820 @default.
- NCIT_C143956 subClassOf NCIT_C143956 @default.
- NCIT_C143956 subClassOf NCIT_C1663 @default.
- NCIT_C143956 subClassOf NCIT_C1908 @default.
- NCIT_C143956 subClassOf NCIT_C1909 @default.
- NCIT_C143956 subClassOf NCIT_C274 @default.
- NCIT_C143956 subClassOf NCIT_C307 @default.
- NCIT_C143956 subClassOf NCIT_C308 @default.
- NCIT_C143956 subClassOf NCIT_C923 @default.