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- NCIT_C146636 IAO_0000115 "A pegylated peptide antagonist that binds to the common gamma chain (gc; IL2RG; CD132) of the signaling receptor for the pro-inflammatory cytokines interleukin (IL)-2, IL-9, and IL-15, with potential immunomodulating and antineoplastic activities. Upon administration, IL-2/9/15 gc receptor inhibitor BNZ-1 specifically targets and binds to the IL binding site on the gc receptor and blocks IL-2, IL-9 and IL-15 binding, thereby inhibiting IL-2-, IL-9-, and IL-15-mediated signaling and downstream pathways. This may inhibit proliferation of tumor cells that are dependent on IL-2/9/15 signaling for their growth. IL-2/9/15 are upregulated in certain tumor cell types and play a key role in tumor progression and survival." @default.
- NCIT_C146636 NCIT_A32 NCIT_C1909 @default.
- NCIT_C146636 NCIT_A7 NCIT_C26266 @default.
- NCIT_C146636 NCIT_NHC0 "C146636" @default.
- NCIT_C146636 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C146636 NCIT_P107 "IL-2/9/15 Gamma Chain Receptor Inhibitor BNZ-1" @default.
- NCIT_C146636 NCIT_P108 "IL-2/9/15 Gamma Chain Receptor Inhibitor BNZ-1" @default.
- NCIT_C146636 NCIT_P208 "CL544668" @default.
- NCIT_C146636 NCIT_P322 "CTRP" @default.
- NCIT_C146636 NCIT_P322 "GDC" @default.
- NCIT_C146636 NCIT_P329 "792153" @default.
- NCIT_C146636 NCIT_P330 "792153" @default.
- NCIT_C146636 NCIT_P375 "IL-2/9/15 Gamma Chain Receptor Inhibitor BNZ-1" @default.
- NCIT_C146636 NCIT_P399 "792153" @default.
- NCIT_C146636 normalizedInformationContent "100" @default.
- NCIT_C146636 referenceCount "1" @default.
- NCIT_C146636 hasExactSynonym "BNZ-1" @default.
- NCIT_C146636 hasExactSynonym "BNZ132-1-40" @default.
- NCIT_C146636 hasExactSynonym "IL-2/9/15 Gamma Chain Receptor Inhibitor BNZ-1" @default.
- NCIT_C146636 inSubset NCIT_C116977 @default.
- NCIT_C146636 inSubset NCIT_C116978 @default.
- NCIT_C146636 inSubset NCIT_C128784 @default.
- NCIT_C146636 inSubset NCIT_C157711 @default.
- NCIT_C146636 inSubset NCIT_C157712 @default.
- NCIT_C146636 inSubset NCIT_C176424 @default.
- NCIT_C146636 inSubset NCIT_C177537 @default.
- NCIT_C146636 type Class @default.
- NCIT_C146636 isDefinedBy ncit.owl @default.
- NCIT_C146636 label "IL-2/9/15 Gamma Chain Receptor Inhibitor BNZ-1" @default.
- NCIT_C146636 subClassOf NCIT_C146636 @default.
- NCIT_C146636 subClassOf NCIT_C1908 @default.
- NCIT_C146636 subClassOf NCIT_C1909 @default.
- NCIT_C146636 subClassOf NCIT_C308 @default.