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- NCIT_C146720 IAO_0000115 "A combination formulation containing the prodrug of netupitant, fosnetupitant, a selective neurokinin 1 receptor (NK1R; TACR1) antagonist, and the hydrochloride salt form of palonosetron, a selective serotonin (5-hydroxytrytamine; 5-HT) receptor subtype 3 (5-HT3R) antagonist, with potential antiemetic activity. Upon intravenous administration, fosnetupitant is converted by phosphatases to its active form netupitant. Netupitant competitively binds to and blocks the activity of NK1Rs in the central nervous system (CNS), by inhibiting binding of the endogenous tachykinin-derived neuropeptide substance P (SP) to NK1R. This prevents delayed emesis, which is associated with SP secretion. Palonosetron competitively blocks the interaction of 5-HT with 5-HT3Rs located on vagal afferent nerves in the chemoreceptor trigger zone (CTZ). This inhibits acute emesis associated with 5-HT secretion and subsequent 5-HT3R activation. Altogether, this results in inhibition of acute and delayed nausea and vomiting, and may prevent chemotherapy-induced nausea and vomiting (CINV)." @default.
- NCIT_C146720 NCIT_A7 NCIT_C105979 @default.
- NCIT_C146720 NCIT_A7 NCIT_C41023 @default.
- NCIT_C146720 NCIT_NHC0 "C146720" @default.
- NCIT_C146720 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C146720 NCIT_P107 "Fosnetupitant/Palonosetron Hydrochloride" @default.
- NCIT_C146720 NCIT_P108 "Fosnetupitant/Palonosetron Hydrochloride" @default.
- NCIT_C146720 NCIT_P208 "CL544714" @default.
- NCIT_C146720 NCIT_P322 "CTRP" @default.
- NCIT_C146720 NCIT_P329 "792159" @default.
- NCIT_C146720 NCIT_P330 "792159" @default.
- NCIT_C146720 NCIT_P399 "792159" @default.
- NCIT_C146720 normalizedInformationContent "100" @default.
- NCIT_C146720 referenceCount "1" @default.
- NCIT_C146720 hasExactSynonym "Fosnetupitant-Palonosetron HCl" @default.
- NCIT_C146720 hasExactSynonym "Fosnetupitant/Palonosetron HCl Combination" @default.
- NCIT_C146720 hasExactSynonym "Fosnetupitant/Palonosetron Hydrochloride" @default.
- NCIT_C146720 hasExactSynonym "IV NEPA FDC" @default.
- NCIT_C146720 hasExactSynonym "Pro-netupitant/Palonosetron" @default.
- NCIT_C146720 hasExactSynonym "Pronetupitant/Palonosetron" @default.
- NCIT_C146720 inSubset NCIT_C116977 @default.
- NCIT_C146720 inSubset NCIT_C116978 @default.
- NCIT_C146720 inSubset NCIT_C176424 @default.
- NCIT_C146720 type Class @default.
- NCIT_C146720 isDefinedBy ncit.owl @default.
- NCIT_C146720 label "Fosnetupitant/Palonosetron Hydrochloride" @default.
- NCIT_C146720 subClassOf NCIT_C146720 @default.
- NCIT_C146720 subClassOf NCIT_C1908 @default.
- NCIT_C146720 subClassOf NCIT_C1909 @default.
- NCIT_C146720 subClassOf NCIT_C267 @default.
- NCIT_C146720 subClassOf NCIT_C78272 @default.