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- NCIT_C146806 IAO_0000115 "Allogeneic, off-the-shelf, universal transcription activator-like effector nuclease (TALEN)-engineered T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) human interleukin-3 receptor alpha chain (IL3RA; cluster of differentiation 123; CD123), with potential immunomodulating and antineoplastic activities. Upon transfusion of allogeneic CD123-specific universal CAR123-expressing T-lymphocytes (UCART123), these cells target and bind to cancer cells expressing CD123. This induces selective toxicity in and causes lysis of CD123-expressing tumor cells. CD123 is normally expressed on committed blood progenitor cells in the bone marrow; its overexpression is associated with both increased leukemic cell proliferation and aggressiveness. Using TALEN technology, the UCART123 cells no longer express the endogenous T-cell receptor (TCR) thereby abrogating the potential induction of graft-versus-host disease (GvHD) by the donor T-cells." @default.
- NCIT_C146806 NCIT_A7 NCIT_C39275 @default.
- NCIT_C146806 NCIT_NHC0 "C146806" @default.
- NCIT_C146806 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C146806 NCIT_P107 "Allogeneic CD123-specific Universal CAR123-expressing T-lymphocytes" @default.
- NCIT_C146806 NCIT_P108 "Allogeneic CD123-specific Universal CAR123-expressing T-lymphocytes" @default.
- NCIT_C146806 NCIT_P208 "CL544763" @default.
- NCIT_C146806 NCIT_P322 "CTRP" @default.
- NCIT_C146806 NCIT_P329 "792167" @default.
- NCIT_C146806 NCIT_P330 "792167" @default.
- NCIT_C146806 NCIT_P399 "792167" @default.
- NCIT_C146806 normalizedInformationContent "100" @default.
- NCIT_C146806 referenceCount "1" @default.
- NCIT_C146806 hasExactSynonym "Allogeneic CD123-specific Universal CAR123-expressing T-lymphocytes" @default.
- NCIT_C146806 hasExactSynonym "Allogeneic Engineered T-cells Expressing Anti-CD123 Chimeric Antigen Receptor" @default.
- NCIT_C146806 hasExactSynonym "UCART123 T Cells" @default.
- NCIT_C146806 hasExactSynonym "UCART123" @default.
- NCIT_C146806 hasExactSynonym "Universal Chimeric Antigen Receptor T-cell 123" @default.
- NCIT_C146806 hasExactSynonym "Universal Chimeric Antigen Receptor T-cells targeting CD123" @default.
- NCIT_C146806 hasExactSynonym "Universal TALEN Gene-edited CART123 Cells" @default.
- NCIT_C146806 inSubset NCIT_C116977 @default.
- NCIT_C146806 inSubset NCIT_C116978 @default.
- NCIT_C146806 inSubset NCIT_C128784 @default.
- NCIT_C146806 inSubset NCIT_C176424 @default.
- NCIT_C146806 type Class @default.
- NCIT_C146806 isDefinedBy ncit.owl @default.
- NCIT_C146806 label "Allogeneic CD123-specific Universal CAR123-expressing T-lymphocytes" @default.
- NCIT_C146806 subClassOf NCIT_C129820 @default.
- NCIT_C146806 subClassOf NCIT_C129821 @default.
- NCIT_C146806 subClassOf NCIT_C129826 @default.
- NCIT_C146806 subClassOf NCIT_C137999 @default.
- NCIT_C146806 subClassOf NCIT_C142078 @default.
- NCIT_C146806 subClassOf NCIT_C146806 @default.
- NCIT_C146806 subClassOf NCIT_C154231 @default.
- NCIT_C146806 subClassOf NCIT_C1908 @default.
- NCIT_C146806 subClassOf NCIT_C1909 @default.
- NCIT_C146806 subClassOf NCIT_C1962 @default.
- NCIT_C146806 subClassOf NCIT_C200765 @default.
- NCIT_C146806 subClassOf NCIT_C201493 @default.
- NCIT_C146806 subClassOf NCIT_C274 @default.
- NCIT_C146806 subClassOf NCIT_C28676 @default.
- NCIT_C146806 subClassOf NCIT_C307 @default.
- NCIT_C146806 subClassOf NCIT_C308 @default.