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- NCIT_C146807 IAO_0000115 "An orally available ataxia telangiectasia and Rad3-related (ATR)-specific kinase inhibitor, with potential antineoplastic activity. Upon oral administration, elimusertib selectively binds to and inhibits the activity of ATR, which prevents ATR-mediated signaling. This inhibits DNA damage checkpoint activation, disrupts DNA damage repair and induces apoptosis in ATR-overexpressing tumor cells. ATR, a serine/threonine protein kinase upregulated in a variety of cancer cell types, plays a key role in DNA repair, cell cycle progression and cell survival." @default.
- NCIT_C146807 NCIT_A32 NCIT_C1909 @default.
- NCIT_C146807 NCIT_A7 NCIT_C21430 @default.
- NCIT_C146807 NCIT_NHC0 "C146807" @default.
- NCIT_C146807 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C146807 NCIT_P107 "Elimusertib" @default.
- NCIT_C146807 NCIT_P108 "Elimusertib" @default.
- NCIT_C146807 NCIT_P208 "CL544748" @default.
- NCIT_C146807 NCIT_P210 "1876467-74-1" @default.
- NCIT_C146807 NCIT_P319 "7N13IK9LNH" @default.
- NCIT_C146807 NCIT_P322 "CTRP" @default.
- NCIT_C146807 NCIT_P322 "FDA" @default.
- NCIT_C146807 NCIT_P322 "GDC" @default.
- NCIT_C146807 NCIT_P329 "792166" @default.
- NCIT_C146807 NCIT_P330 "792166" @default.
- NCIT_C146807 NCIT_P375 "ATR Kinase Inhibitor BAY1895344" @default.
- NCIT_C146807 NCIT_P399 "792166" @default.
- NCIT_C146807 normalizedInformationContent "100" @default.
- NCIT_C146807 referenceCount "1" @default.
- NCIT_C146807 hasExactSynonym "ATR Inhibitor BAY1895344" @default.
- NCIT_C146807 hasExactSynonym "ATR Kinase Inhibitor BAY1895344" @default.
- NCIT_C146807 hasExactSynonym "BAY 1895344" @default.
- NCIT_C146807 hasExactSynonym "BAY-1895344" @default.
- NCIT_C146807 hasExactSynonym "BAY1895344" @default.
- NCIT_C146807 hasExactSynonym "ELIMUSERTIB" @default.
- NCIT_C146807 hasExactSynonym "Elimusertib" @default.
- NCIT_C146807 inSubset NCIT_C116977 @default.
- NCIT_C146807 inSubset NCIT_C116978 @default.
- NCIT_C146807 inSubset NCIT_C128784 @default.
- NCIT_C146807 inSubset NCIT_C157711 @default.
- NCIT_C146807 inSubset NCIT_C157712 @default.
- NCIT_C146807 inSubset NCIT_C176424 @default.
- NCIT_C146807 inSubset NCIT_C177537 @default.
- NCIT_C146807 inSubset NCIT_C63923 @default.
- NCIT_C146807 type Class @default.
- NCIT_C146807 isDefinedBy ncit.owl @default.
- NCIT_C146807 label "Elimusertib" @default.
- NCIT_C146807 subClassOf NCIT_C129824 @default.
- NCIT_C146807 subClassOf NCIT_C129825 @default.
- NCIT_C146807 subClassOf NCIT_C1404 @default.
- NCIT_C146807 subClassOf NCIT_C146807 @default.
- NCIT_C146807 subClassOf NCIT_C155926 @default.
- NCIT_C146807 subClassOf NCIT_C1908 @default.
- NCIT_C146807 subClassOf NCIT_C1909 @default.
- NCIT_C146807 subClassOf NCIT_C2189 @default.
- NCIT_C146807 subClassOf NCIT_C274 @default.
- NCIT_C146807 subClassOf NCIT_C471 @default.
- NCIT_C146807 subClassOf NCIT_C61074 @default.