Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C146810> ?p ?o ?g. }
Showing items 1 to 44 of
44
with 100 items per page.
- NCIT_C146810 IAO_0000115 "An orally available covalent inhibitor of human epidermal growth factor receptor 2 (HER2; ERBB2), with potential antineoplastic activity. Upon oral administration, HER2 inhibitor TAS0728 specifically and irreversibly binds to and inhibits the activity of HER2. This prevents HER2-mediated signaling and leads to cell death in HER2- and HER3 (ErbB3)-expressing tumor cells. HER2, a receptor tyrosine kinase mutated or overexpressed in many tumor cell types, play key roles in tumor cell proliferation and tumor vascularization. HER3 has no active kinase domain but is activated through heterodimerization with other members of the EGFR receptor family, such as HER2." @default.
- NCIT_C146810 NCIT_A32 NCIT_C1909 @default.
- NCIT_C146810 NCIT_A7 NCIT_C17319 @default.
- NCIT_C146810 NCIT_NHC0 "C146810" @default.
- NCIT_C146810 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C146810 NCIT_P107 "HER2 Inhibitor TAS0728" @default.
- NCIT_C146810 NCIT_P108 "HER2 Inhibitor TAS0728" @default.
- NCIT_C146810 NCIT_P208 "CL544751" @default.
- NCIT_C146810 NCIT_P322 "CTRP" @default.
- NCIT_C146810 NCIT_P322 "GDC" @default.
- NCIT_C146810 NCIT_P329 "792168" @default.
- NCIT_C146810 NCIT_P330 "792168" @default.
- NCIT_C146810 NCIT_P375 "HER2 Inhibitor TAS0728" @default.
- NCIT_C146810 NCIT_P399 "792168" @default.
- NCIT_C146810 normalizedInformationContent "100" @default.
- NCIT_C146810 referenceCount "1" @default.
- NCIT_C146810 hasExactSynonym "HER2 Inhibitor TAS0728" @default.
- NCIT_C146810 hasExactSynonym "TAS 0728" @default.
- NCIT_C146810 hasExactSynonym "TAS-0728" @default.
- NCIT_C146810 hasExactSynonym "TAS0728" @default.
- NCIT_C146810 hasExactSynonym "TPC-107" @default.
- NCIT_C146810 inSubset NCIT_C116977 @default.
- NCIT_C146810 inSubset NCIT_C116978 @default.
- NCIT_C146810 inSubset NCIT_C128784 @default.
- NCIT_C146810 inSubset NCIT_C157711 @default.
- NCIT_C146810 inSubset NCIT_C157712 @default.
- NCIT_C146810 inSubset NCIT_C176424 @default.
- NCIT_C146810 inSubset NCIT_C177537 @default.
- NCIT_C146810 type Class @default.
- NCIT_C146810 isDefinedBy ncit.owl @default.
- NCIT_C146810 label "HER2 Inhibitor TAS0728" @default.
- NCIT_C146810 subClassOf NCIT_C129824 @default.
- NCIT_C146810 subClassOf NCIT_C129825 @default.
- NCIT_C146810 subClassOf NCIT_C1404 @default.
- NCIT_C146810 subClassOf NCIT_C146810 @default.
- NCIT_C146810 subClassOf NCIT_C159156 @default.
- NCIT_C146810 subClassOf NCIT_C163758 @default.
- NCIT_C146810 subClassOf NCIT_C163760 @default.
- NCIT_C146810 subClassOf NCIT_C1908 @default.
- NCIT_C146810 subClassOf NCIT_C1909 @default.
- NCIT_C146810 subClassOf NCIT_C1967 @default.
- NCIT_C146810 subClassOf NCIT_C2189 @default.
- NCIT_C146810 subClassOf NCIT_C274 @default.
- NCIT_C146810 subClassOf NCIT_C471 @default.