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- NCIT_C146813 IAO_0000115 "An mRNA-based individualized, therapeutic personalized cancer vaccine (PCV) targeting twenty tumor-associated antigens (TAAs) that are specifically expressed by the patient's cancer cells, with potential immunostimulatory and antineoplastic activities. The cells from the patient's tumor are analyzed, and genetic sequencing is used to identify twenty neoantigen epitopes that may elicit the strongest immune response in the patient. The sequences encoding the twenty patient-specific epitopes are transcribed and loaded onto a single mRNA molecule. Upon administration, the mRNA-based PCV mRNA-4157 is taken up and translated by antigen presenting cells (APCs). Then, the expressed epitopes are presented via major histocompatibility complex (MHC) molecules on the surface of the APCs. This leads to an induction of both cytotoxic T-lymphocyte (CTL)- and memory T-cell-dependent immune responses that specifically target and destroy the patient's cancer cells that express these neoantigens." @default.
- NCIT_C146813 NCIT_A32 NCIT_C1909 @default.
- NCIT_C146813 NCIT_NHC0 "C146813" @default.
- NCIT_C146813 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C146813 NCIT_P107 "mRNA-based Personalized Cancer Vaccine mRNA-4157" @default.
- NCIT_C146813 NCIT_P108 "mRNA-based Personalized Cancer Vaccine mRNA-4157" @default.
- NCIT_C146813 NCIT_P208 "CL544754" @default.
- NCIT_C146813 NCIT_P322 "CTRP" @default.
- NCIT_C146813 NCIT_P322 "GDC" @default.
- NCIT_C146813 NCIT_P329 "792256" @default.
- NCIT_C146813 NCIT_P330 "792256" @default.
- NCIT_C146813 NCIT_P375 "mRNA-based Personalized Cancer Vaccine mRNA-4157" @default.
- NCIT_C146813 NCIT_P399 "792256" @default.
- NCIT_C146813 normalizedInformationContent "100" @default.
- NCIT_C146813 referenceCount "1" @default.
- NCIT_C146813 hasExactSynonym "PCV mRNA-4157" @default.
- NCIT_C146813 hasExactSynonym "V 940" @default.
- NCIT_C146813 hasExactSynonym "V-940" @default.
- NCIT_C146813 hasExactSynonym "V940" @default.
- NCIT_C146813 hasExactSynonym "mRNA 4157" @default.
- NCIT_C146813 hasExactSynonym "mRNA-4157" @default.
- NCIT_C146813 hasExactSynonym "mRNA-based PCV mRNA-4157" @default.
- NCIT_C146813 hasExactSynonym "mRNA-based Personalized Cancer Vaccine mRNA-4157" @default.
- NCIT_C146813 inSubset NCIT_C116977 @default.
- NCIT_C146813 inSubset NCIT_C116978 @default.
- NCIT_C146813 inSubset NCIT_C128784 @default.
- NCIT_C146813 inSubset NCIT_C157711 @default.
- NCIT_C146813 inSubset NCIT_C157712 @default.
- NCIT_C146813 inSubset NCIT_C176424 @default.
- NCIT_C146813 inSubset NCIT_C177537 @default.
- NCIT_C146813 type Class @default.
- NCIT_C146813 isDefinedBy ncit.owl @default.
- NCIT_C146813 label "mRNA-based Personalized Cancer Vaccine mRNA-4157" @default.
- NCIT_C146813 subClassOf NCIT_C129820 @default.
- NCIT_C146813 subClassOf NCIT_C146813 @default.
- NCIT_C146813 subClassOf NCIT_C1663 @default.
- NCIT_C146813 subClassOf NCIT_C172787 @default.
- NCIT_C146813 subClassOf NCIT_C181141 @default.
- NCIT_C146813 subClassOf NCIT_C1908 @default.
- NCIT_C146813 subClassOf NCIT_C1909 @default.
- NCIT_C146813 subClassOf NCIT_C274 @default.
- NCIT_C146813 subClassOf NCIT_C307 @default.
- NCIT_C146813 subClassOf NCIT_C308 @default.
- NCIT_C146813 subClassOf NCIT_C923 @default.