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- NCIT_C1470 IAO_0000115 "A guanine ribonucleotide derivative with immunostimulatory and immunomodulatory activity. Loxoribine undergoes facilitated transport across the plasma membrane into the cytoplasmic compartment of the cell and acts intracellularly, bypassing the biochemical steps involved in the membrane signal transduction pathway used by Ag or anti-IgM Abs to activate B cells. This agent activates the Toll-like receptor 7 (TLR7), a member of the TLR family of pathogen-associated molecular pattern recognition receptors thereby activating the innate immune system. This activation requires endosomal maturation and recognition is restricted to TLR7. As a result, loxoribine induces cycling B cells to proliferate and differentiate non-specifically and recruit antigen-reactive B cells to undergo differentiation to antibody production, markedly amplifying the underlying response in the process." @default.
- NCIT_C1470 NCIT_NHC0 "C1470" @default.
- NCIT_C1470 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C1470 NCIT_P106 "Organic Chemical" @default.
- NCIT_C1470 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C1470 NCIT_P108 "Loxoribine" @default.
- NCIT_C1470 NCIT_P207 "C0209660" @default.
- NCIT_C1470 NCIT_P210 "121288-39-9" @default.
- NCIT_C1470 NCIT_P319 "9CAS0V66OI" @default.
- NCIT_C1470 NCIT_P322 "FDA" @default.
- NCIT_C1470 NCIT_P329 "41358" @default.
- NCIT_C1470 NCIT_P330 "41358" @default.
- NCIT_C1470 NCIT_P350 "C13H17N5O6" @default.
- NCIT_C1470 NCIT_P366 "Loxoribine" @default.
- NCIT_C1470 NCIT_P399 "41358" @default.
- NCIT_C1470 normalizedInformationContent "100" @default.
- NCIT_C1470 referenceCount "1" @default.
- NCIT_C1470 hasExactSynonym "7-Allyl-8-oxoguanosine" @default.
- NCIT_C1470 hasExactSynonym "LOXORIBINE" @default.
- NCIT_C1470 hasExactSynonym "Loxoribine" @default.
- NCIT_C1470 inSubset NCIT_C176424 @default.
- NCIT_C1470 inSubset NCIT_C63923 @default.
- NCIT_C1470 type Class @default.
- NCIT_C1470 isDefinedBy ncit.owl @default.
- NCIT_C1470 label "Loxoribine" @default.
- NCIT_C1470 subClassOf NCIT_C1470 @default.
- NCIT_C1470 subClassOf NCIT_C1908 @default.
- NCIT_C1470 subClassOf NCIT_C1909 @default.
- NCIT_C1470 subClassOf NCIT_C210 @default.
- NCIT_C1470 subClassOf NCIT_C2140 @default.
- NCIT_C1470 subClassOf NCIT_C2554 @default.
- NCIT_C1470 subClassOf NCIT_C308 @default.