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- NCIT_C147031 IAO_0000115 "An antibody-drug conjugate (ADC) composed of a monoclonal antibody against human mucin 16 (MUC16; cancer antigen 125; CA125; FLJ14303) conjugated to monomethyl auristatin E (MMAE), an auristatin derivative and potent microtubule disrupting agent, with potential antineoplastic activity. Upon administration, anti-MUC16/MMAE ADC DMUC4064A binds to MUC16 located on the tumor cell surface. After internalization of the agent, the MMAE moiety is released and binds to tubulin and inhibits its polymerization, which results in G2/M phase arrest and apoptosis. MUC16, a member of the mucin family glycoproteins, is overexpressed in a variety of tumor cells and plays a key role in tumor cell proliferation." @default.
- NCIT_C147031 NCIT_A32 NCIT_C1909 @default.
- NCIT_C147031 NCIT_A7 NCIT_C71020 @default.
- NCIT_C147031 NCIT_NHC0 "C147031" @default.
- NCIT_C147031 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C147031 NCIT_P107 "Anti-MUC16/MMAE Antibody-Drug Conjugate DMUC4064A" @default.
- NCIT_C147031 NCIT_P108 "Anti-MUC16/MMAE Antibody-Drug Conjugate DMUC4064A" @default.
- NCIT_C147031 NCIT_P208 "CL545030" @default.
- NCIT_C147031 NCIT_P319 "D5STG0624V" @default.
- NCIT_C147031 NCIT_P322 "CTRP" @default.
- NCIT_C147031 NCIT_P322 "FDA" @default.
- NCIT_C147031 NCIT_P322 "GDC" @default.
- NCIT_C147031 NCIT_P329 "792380" @default.
- NCIT_C147031 NCIT_P330 "792380" @default.
- NCIT_C147031 NCIT_P375 "Anti-MUC16/MMAE Antibody-Drug Conjugate DMUC4064A" @default.
- NCIT_C147031 NCIT_P399 "792380" @default.
- NCIT_C147031 normalizedInformationContent "100" @default.
- NCIT_C147031 referenceCount "1" @default.
- NCIT_C147031 hasExactSynonym "ADC DMUC4064A" @default.
- NCIT_C147031 hasExactSynonym "Anti-MUC16/MMAE Antibody-Drug Conjugate DMUC4064A" @default.
- NCIT_C147031 hasExactSynonym "DMUC-4064A" @default.
- NCIT_C147031 hasExactSynonym "DMUC4064A" @default.
- NCIT_C147031 hasExactSynonym "RG7882" @default.
- NCIT_C147031 hasExactSynonym "THIOMAB-drug Conjugate DMUC4064A" @default.
- NCIT_C147031 inSubset NCIT_C116977 @default.
- NCIT_C147031 inSubset NCIT_C116978 @default.
- NCIT_C147031 inSubset NCIT_C128784 @default.
- NCIT_C147031 inSubset NCIT_C157711 @default.
- NCIT_C147031 inSubset NCIT_C157712 @default.
- NCIT_C147031 inSubset NCIT_C176424 @default.
- NCIT_C147031 inSubset NCIT_C177537 @default.
- NCIT_C147031 inSubset NCIT_C63923 @default.
- NCIT_C147031 type Class @default.
- NCIT_C147031 isDefinedBy ncit.owl @default.
- NCIT_C147031 label "Anti-MUC16/MMAE Antibody-Drug Conjugate DMUC4064A" @default.
- NCIT_C147031 subClassOf NCIT_C147031 @default.
- NCIT_C147031 subClassOf NCIT_C1512 @default.
- NCIT_C147031 subClassOf NCIT_C1908 @default.
- NCIT_C147031 subClassOf NCIT_C1909 @default.
- NCIT_C147031 subClassOf NCIT_C307 @default.
- NCIT_C147031 subClassOf NCIT_C308 @default.